Publications de Daniel Keller | EPFL Graph Search

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

Henry Markram, James Gonzalo King, Daniel Keller, James Bryden Isbister, Polina Shichkova, Darshan Mandge, Alessandro Cattabiani

The high energetic demands of the brain arise primarily from neuronal activity. Neurons consume substantial energy to transmit information as electrical signals and maintain their resting membrane potential. These energetic requirements are met by the neur ...

Public Library of Science (PLoS)2025

Seizure and redox rescue in a model of glucose transport deficiency

Henry Markram, Daniel Keller, Polina Shichkova

Disruptions of energy supply to the brain are associated with many neurodegenerative pathologies and are difficult to study due to numerous interlinked metabolic pathways. We explored the effects of diminished energy supply on brain metabolism using a comp ...

2025

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Adrien Michel Achille Devresse

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024

Structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex

Henry Markram, Giovanna Ambrosini, Romain Guiet, Nicolas René Chiaruttini, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Elvis Boci

The relation of astrocytic endfeet to the vasculature plays a key functional role in the neuro‐glia‐vasculature unit. We characterize the spatial organization of astrocytes and the structural aspects that facilitate their involvement in molecular exchanges ...

Wiley2024

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Rajnish Ranjan, Armando Romani, Mustafa Anil Tuncel, Aleksandra Zuzanna Teska, Polina Litvak

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

2024

Cell density quantification of high resolution Nissl images of the juvenile rat brain

Henry Markram, Olivier Burri, Rodrigo de Campos Perin, Ying Shi, Julie Meystre, Daniel Keller

Copyright © 2024 Meystre, Jacquemier, Burri, Zsolnai, Frank, Vieira, Shi, Perin, Keller and Markram.Nissl histology underpins our understanding of brain anatomy and architecture. Despite its importance, no high-resolution datasets are currently available i ...

2024

Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes

Henry Markram, Daniel Keller, Jay Coggan, Polina Shichkova

The regulation of energy in the brain has garnered substantial attention in recent years due to its significant implications in various disorders and aging. The brain’s energy metabolism is a dynamic and tightly regulated network that balances energy deman ...

MDPI AG2024

Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling

Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Jay Coggan, Georges Khazen, Judit Planas Carbonell, Elvis Boci, Nadir Roman Guerrero, Juan José García Cantero, Alessandro Enrico Foni

Understanding the intracellular dynamics of brain cells entails performing three-dimensional molecular simulations incorporating ultrastructural models that can capture cellular membrane geometries at nanometer scales. While there is an abundance of neuron ...

Oxford University Press (OUP)2024

Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Nadir Roman Guerrero, Juan José García Cantero, Alessandro Enrico Foni, Eleftherios Zisis

Ultraliser is a neuroscience-specific software framework capable of creating accurate and biologically realistic 3D models of complex neuroscientific structures at intracellular (e.g. mitochondria and endoplasmic reticula), cellular (e.g. neurons and glia) ...

2023

Cell-type-specific densities in mouse somatosensory cortex derived from scRNA-seq and in situ RNA hybridization

Henry Markram, Daniel Keller

Cells in the mammalian cerebral cortex exhibit layer-dependent patterns in their distribution. Classical methods of determining cell type distributions typically employ a painstaking process of large-scale sampling and characterization of cellular composit ...

FRONTIERS MEDIA SA2023