Daniel Keller

Cette personne n’est plus à l’EPFL

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Publications associées (37)

Mapping of morpho-electric features to molecular identity of cortical inhibitory neurons

Henry Markram, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Yann Roussel, Tanguy Pierre Louis Damart, Dimitri Bruno Marie Rodarie

Author summaryThe computational abilities of the brain arise from its organization principles at the cellular level. One of these principles is the neuronal type composition over different regions. Since computational functions of neurons are best describe ...

2023

A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience

Daniel Keller, Andrii Stepaniuk

Neuroscience incorporates knowledge from a range of scales, from single molecules to brain wide neural networks. Modeling is a valuable tool in understanding processes at a single scale or the interactions between two adjacent scales and researchers use a ...

HUMANA PRESS INC2022

A method to estimate the cellular composition of the mouse brain from heterogeneous datasets

Henry Markram, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Marc-Oliver Gewaltig, Yann Roussel, Dimitri Bruno Marie Rodarie

The mouse brain contains a rich diversity of inhibitory neuron types that have been characterized by their patterns of gene expression. However, it is still unclear how these cell types are distributed across the mouse brain. We developed a computational m ...

2022

Representing stimulus information in an energy metabolism pathway

Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan

We explored a computational model of astrocytic energy metabolism and demonstrated the theoretical plausibility that this type of pathway might be capable of coding information about stimuli in addition to its known functions in cellular energy and carbon ...

2022

Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows

Daniel Keller

Modeling in neuroscience occurs at the intersection of different points of view and approaches. Typically, hypothesis-driven modeling brings a question into focus so that a model is constructed to investigate a specific hypothesis about how the system work ...

2022

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Henry Markram, Emmanuelle Logette, Samuel Claude Kerrien, Enrico Scantamburlo, Daniel Keller, Jay Coggan, Cyrille Pierre Henri Favreau, Francesco Casalegno, Mohameth François Sy, Anna-Kristin Kaufmann

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that reached pandemic proportions among the human population within months. The reasons for the spectrum of differences in the severity of the disease across the population, an ...

FRONTIERS MEDIA SA2021

Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Samuel Lieven D. Lapere, Nadir Roman Guerrero, Alessandro Enrico Foni, Eleftherios Zisis

Motivation: Astrocytes, the most abundant glial cells in the mammalian brain, have an instrumental role in developing neuronal circuits. They contribute to the physical structuring of the brain, modulating synaptic activity and maintaining the blood-brain ...

OXFORD UNIV PRESS2021

A Standardized Brain Molecular Atlas: A Resource for Systems Modeling and Simulation

Henry Markram, Daniel Keller, Jay Coggan, Polina Shichkova

Accurate molecular concentrations are essential for reliable analyses of biochemical networks and the creation of predictive models for molecular and systems biology, yet protein and metabolite concentrations used in such models are often poorly constraine ...

FRONTIERS MEDIA SA2021

Supervised Learning With Perceptual Similarity for Multimodal Gene Expression Registration of a Mouse Brain Atlas

Henry Markram, Felix Schürmann, Daniel Keller, Huanxiang Lu, Francesco Casalegno, Csaba Erö, Dimitri Bruno Marie Rodarie

The acquisition of high quality maps of gene expression in the rodent brain is of fundamental importance to the neuroscience community. The generation of such datasets relies on registering individual gene expression images to a reference volume, a task en ...

FRONTIERS MEDIA SA2021

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Henry Markram, Kathryn Hess Bellwald, Lida Kanari, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Alexis Arnaudon, Corrado Cali, Michael Emiel Gevaert, Thomas Brice Delemontex

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interaction ...

OXFORD UNIV PRESS INC2021

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Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Samuel Lieven D. Lapere, Nadir Roman Guerrero, Alessandro Enrico Foni, Eleftherios Zisis

OXFORD UNIV PRESS2021