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Daniel Keller

Cette personne n’est plus à l’EPFL

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Publications associées (37)

Interactive visualization and analysis of morphological skeletons of brain vasculature networks with VessMorphoVis

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Jay Coggan, Samuel Lieven D. Lapere, Nadir Roman Guerrero, Benoît Jean-Albert Coste

Motivation: Accurate morphological models of brain vasculature are key to modeling and simulating cerebral blood flow in realistic vascular networks. This in silico approach is fundamental to revealing the principles of neurovascular coupling. Validating t ...

OXFORD UNIV PRESS2020

Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan

With a computational model of energy metabolism in an astrocyte, we show how a system of enzymes in a cascade can act as a functional unit of interdependent reactions, rather than merely a series of independent reactions. These systems may exist in multipl ...

2020

Corrigendum: A Cell Atlas for the Mouse Brain

Henry Markram, Daniel Keller, Marc-Oliver Gewaltig, Csaba Erö

2019

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

2019

A Derived Positional Mapping of Inhibitory Subtypes in the Somatosensory Cortex

Henry Markram, Olivier Burri, Romain Guiet, Julie Meystre, Felix Schürmann, Daniel Keller, Rahul Valiya Veettil

Obtaining a catalog of cell types is a fundamental building block for understanding the brain. The ideal classification of cell-types is based on the profile of molecules expressed by a cell, in particular, the profile of genes expressed. One strategy is, ...

2019

A Cell Atlas for the Mouse Brain

Henry Markram, Daniel Keller, Marc-Oliver Gewaltig

Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. ...

2018

Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2

Daniel Keller, Aditya Kumar

2018

Cell Densities in the Mouse Brain: A Systematic Review

Henry Markram, Daniel Keller, Csaba Erö

The mouse brain is the most extensively studied brain of all species. We performed an exhaustive review of the literature to establish our current state of knowledge on cell numbers in mouse brain regions, arguably the most fundamental property to measure ...

2018

A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Renaud Jolivet, Corrado Cali, Stefan Eilemann, Jay Coggan, Daniya Boges

One will not understand the brain without an integrated exploration of structure and function, these attributes being two sides of the same coin: together they form the currency of biological computation. Accordingly, biologically realistic models require ...

2018

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Corrado Cali, Jay Coggan

Although efficient compared to computers, the human brain utilizes energy at 10-fold the rate of other organs by mass. How the brain is supplied with sufficient on-demand energy to support its activity in the absence of neuronal storage capacity remains un ...

2018

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A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Renaud Jolivet, Corrado Cali, Stefan Eilemann, Jay Coggan, Daniya Boges

2018

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Corrado Cali, Jay Coggan

2018

Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan

2020

Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2

Daniel Keller, Aditya Kumar

2018