Personne
Francesco Stellacci
Publications associées (192)
Virucidal compounds and use thereof
Francesco Stellacci, Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Corey Alfred Stevens, Francesca Olgiati, Chiara Medaglia, Lukasz Richter
Disclosed herein are peptide-grafted compounds that irreversibly deactivate bacteriophages or influenza virus depending on the peptide and remain safe for bacteria and mammalian cells. The active compounds comprise a core (cyclodextrin or gold nanoparticle ...
2024Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin
Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu, Marine Batista, Andrey Sysoev
We have reported that CD-6'SLN [6-sialyllactosamine (6'SLN)-modified beta-cyclodextrin (CD)] can be a potential anti-influenza drug because it irreversibly deactivates virions. Indeed, in vivo, CD-6'SLN improved mice survival in an H1N1 infection model eve ...
MDPI2023Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery
Francesco Stellacci, Paulo Henrique Jacob Silva, Ester Canepa, Giulia Rossi
Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...
WILEY-V C H VERLAG GMBH2023Virucidal compositions and use thereof
The invention relates to substituted cyclodextrin (CD) compounds having C9 to C25 optionally substituted alkyl-based linker groups, which irreversibly inhibit viruses and are useful in the treatment of viral infections. While the compounds of the invention ...
2023Recycling of Polymerase Chain Reaction (PCR) Kits
Francesco Stellacci, Weina Liu, Yong Zhu
Polymerase chain reaction (PCR) kits have been used as common diagnosing tools during the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with daily worldwide usage in the millions. It is well known that at the beginn ...
AMER CHEMICAL SOC2023Antiviral compounds, compositions and uses thereof
Francesco Stellacci, Matteo Gasbarri, Yong Zhu
Compounds, compositions and methods that can be used for the treatment of viral diseases are provided. ...
2023Influence of structural dynamics on cell uptake investigated with single-chain polymeric nanoparticles
Francesco Stellacci, Lixia Wei, Arthur Eliot Bouchez, Suiyang Liao
Most nanoparticles' parameters affect their interactions with cells. To date, all the parameters studied are basically static (e.g., size, shape, ligands, and charge). This is unfortunate, because proteins have struc-tural dynamics that most nanoparticles ...
CELL PRESS2023Stress granules quantification on fixed and live cells
Francesco Stellacci, Romain Guiet, Xufeng Xu
The custom script was written based on Fiji for measuring the number or size of stress granules inside fixed cells (using a fixed threshold) or live cells (using a local maximum). It allows the batch image data processing for the study of the effects of di ...
Zenodo2023Simultaneous Electrophysiology and Imaging Reveal Changes in Lipid Membrane Thickness and Tension upon Uptake of Amphiphilic Gold Nanoparticles
Francesco Stellacci, Paulo Henrique Jacob Silva, Xufeng Xu, Camilla Servidio
Amphiphilic gold core nanoparticles (AmNPs) striped with hydrophilic 11-mercapto-1-undecanesulfonate (MUS) and hydrophobic 1-octanethiol (OT) ligands are promising candidates for drug carriers that passively and nondisruptively enter cells. Yet, how they i ...
Washington2023Difference in astringency of the main pea protein fractions
Francesco Stellacci, Hanna Fanny Clarisse Lesme
Interactions between food and saliva govern complex mouthfeel perceptions such as astringency. Herein, we present a study of the interactions of salivary proteins with the main pea protein fractions that are obtained by isoelectric and salt precipitation ( ...
London2023