Publications de Francesco Stellacci

Reliable and robust robotic handling of microplates via computer vision and touch feedback

Francesco Stellacci, Josephine Anna Eleanor Hughes

Laboratory automation requires reliable and precise handling of microplates, but existing robotic systems often struggle to achieve this, particularly when navigating around the dynamic and variable nature of laboratory environments. This work introduces a ...

FRONTIERS MEDIA SA2025

Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection (Adv. Mater. 3/2025)

Francesco Stellacci, Heyun Wang, Matteo Gasbarri

Wiley2025

Cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Francesco Stellacci, Quy Ong Khac, Lixia Wei

A method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject includes: (a) determining the protein level of at least one protein in the sample of isolated cholesterol-rich lipoprotein nanoparti ...

2025

Facile lipid nanoparticle size engineering approach via controllable fusion induced by depletion forces

Francesco Stellacci, Milena Maria Schuhmacher, Heyun Wang

Lipid nanoparticles (LNPs) are among the most promising drug delivery carriers in research and development, with one major clinical application being messenger RNA (mRNA) vaccine. Current LNP production methods have the limit of generating low polydispersi ...

2025

Influenza A(H1N1)pdm09 virus resistance to baloxavir, oseltamivir and sialic acid mimetics in single and dual therapies: Insights from human airway epithelia and murine models

Francesco Stellacci

Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. We previously developed two novel HA-targeting compound ...

Elsevier BV2025

Protecting bacteriophages under UV irradiation with brilliant blue FCF for targeted bacterial control

Francesco Stellacci

Compared to the standard methods for treating bacterial diseases, bacteriophages are eco-friendly and chemical-free. Exposure to ultraviolet (UV) light or sunlight hampers the efficacy of phage-based approaches. This is crucial when phages are i) exposed t ...

2025

Physical determinants of nanoparticle-mediated lipid membrane fusion

Francesco Stellacci

A wide range of fundamental cellular activities rely on lipid membrane fusion. Membrane fusion processes can be mimicked by synthetic approaches to understand fusion mechanisms and develop novel drug delivery systems and therapeutic agents. Recently, membr ...

ROYAL SOC CHEMISTRY2025

Efficient Direct Cytosolic Protein Delivery via Protein-Linker Co-engineering

Francesco Stellacci, Heyun Wang, Lixia Wei, Suiyang Liao

Protein therapeutics have enormous potential for transforming the treatment of intracellular cell disorders, such as genetic disorders and cancers. Due to proteins’ cell-membrane impermeability, protein-based drugs against intracellular targets require eff ...

American Chemical Society (ACS)2025

Lyotropy as a Design Consideration for Ultra-Small Protein Nanoparticles via Electrohydrodynamic Jetting

Francesco Stellacci, Quy Ong Khac

Protein-based nanoparticles offer tailored bioactivity and biodegradability that are distinct from their synthetic polymeric counterparts. Precise engineering of physical properties, especially size, of nanoparticles using electrohydrodynamic (EHD) jetting ...

2025

Size distributions and fractograms of cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Francesco Stellacci, Quy Ong Khac, Lixia Wei

The present invention relates to a method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject comprising (α) determining the size distribution or the fractogram in chromatography of the cholest ...

2025