Publications de Istvan Bartha | EPFL Graph Search

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Jacques Fellay, Christian Axel Wandall Thorball, Istvan Bartha

HIV-1 remains a global health crisis(1), highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa(2), we assessed the genetic determinants of control of set-point ...

NATURE PORTFOLIO2023

Functional characterization of 3D protein structures informed by human genetic diversity

Amalio Telenti, Istvan Bartha, Julia di Iulio

Sequence variation data of the human proteome can be used to analyze 3D protein structures to derive functional insights. We used genetic variant data from nearly 140,000 individuals to analyze 3D positional conservation in 4,715 proteins and 3,951 homolog ...

National Academy of Sciences2019

Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes

Jacques Fellay, Olivier Noël Marie Naret, Istvan Bartha, Christian Hammer, Nimisha Chaturvedi

2018

The human noncoding genome defined by genetic diversity

Istvan Bartha, Julia di Iulio

2018

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

Jacques Fellay, Istvan Bartha, Nimisha Chaturvedi, David Smith

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 5 ...

Nature Publishing Group2017

Severe viral respiratory infections in children with IFIH1 loss-of-function mutations

Jacques Fellay, Amalio Telenti, Istvan Bartha, Christian Hammer, Samira Asgari, Thomas Junier, Paul Jack Mc Laren

Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children. To investigate a potential genetic cause, we recruited 120 previously healthy children requiring ...

Natl Acad Sciences2017

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

Jacques Fellay, Amalio Telenti, Istvan Bartha, Paul Jack Mc Laren

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variat ...

Public Library of Science2017

Evaluating the Impact of Functional Genetic Variation on HIV-1 Control

Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. ...

Oxford Univ Press Inc2017

Privacy-preserving genomic testing in the clinic: a model using HIV treatment

Jean-Pierre Hubaux, Jacques Fellay, Paul Jack Mc Laren, Amalio Telenti, Erman Ayday, Jean Louis Raisaro, Istvan Bartha

The implementation of genomic-based medicine is hindered by unresolved questions regarding data privacy and delivery of interpreted results to health-care practitioners. We used DNA-based prediction of HIV-related outcomes as a model to explore critical is ...

Nature Publishing Group2016

Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study

Jacques Fellay, Istvan Bartha, Thomas Junier

Background. The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors. Methods. In the general population, 6 common single-nucleotide p ...

Oxford University Press (OUP)2016