Publications de Arielle Louise Planchette

Assessment of neurobehavioural traits under gnotobiotic conditions: an approach for multiple analyses in the same mouse

Aleksandra Radenovic, Raphaël Doenlen, Arielle Louise Planchette

The gut-microbiota-brain axis influences neuroinflammation, neural development and behaviour such as sociability, memory and anxiety. To study these traits in vivo, especially during development or disease, it is crucial to analyse them over time and with ...

2025

Optical imaging of the small intestine immune compartment across scales

Aleksandra Radenovic, Olivier Burri, Arielle Louise Planchette, Alessio Mylonas

The limitations of 2D microscopy constrain our ability to observe and understand tissue-wide networks that are, by nature, 3-dimensional. Optical projection tomography (OPT) enables the acquisition of large volumes (ranging from micrometres to centimetres) ...

NATURE PORTFOLIO2023

Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer's Disease

Arielle Louise Planchette

The search for an understanding of the causal elements that lead to neurodegenerative diseases has motivated researchers for decades. Today, Alzheimer's disease is the most prevalent form of dementia and affects approximately fifty million people worldwide ...

EPFL2022

Statistical distortion of supervised learning predictions in optical microscopy induced by image compression

Aleksandra Radenovic, Arielle Louise Planchette, David Nguyen

The growth of data throughput in optical microscopy has triggered the extensive use of supervised learning (SL) models on compressed datasets for automated analysis. Investigating the effects of image compression on SL predictions is therefore pivotal to a ...

Nature Portfolio2022

High resolution optical projection tomography platform for multispectral imaging of the mouse gut

Aleksandra Radenovic, Arielle Louise Planchette, Alessio Mylonas, Adrien Charles-François Raymond Descloux

Optical projection tomography (OPT) is a powerful tool for three-dimensional imaging of mesoscopic biological samples with great use for biomedical phenotyping studies. We present a fluorescent OPT platform that enables direct visualization of biological s ...

2021

Supervised learning to quantify amyloidosis in whole brains of an Alzheimer's disease mouse model acquired with optical projection tomography

Dimitri Nestor Alice Van De Ville, Theo Lasser, Aleksandra Radenovic, Paul James Marchand, Arielle Louise Planchette, Virginie Sophie Uhlmann, David Nguyen

Alzheimer's disease (AD) is characterized by amyloidosis of brain tissues. This phenomenon is studied with genetically-modified mouse models. We propose a method to quantify amyloidosis in whole 5xFAD mouse brains, a model of AD. We use optical projection ...

2019

Optical projection tomography for rapid whole mouse brain imaging

Theo Lasser, Dimitri Nestor Alice Van De Ville, Jessica Sordet, Paul James Marchand, Arielle Louise Planchette, David Nguyen, Miguel Sison, Jérôme Extermann, Antonio Lopez, Marcin Antoni Sylwestrzak

In recent years, three-dimensional mesoscopic imaging has gained significant importance in life sciences for fundamental studies at the whole-organ level. In this manuscript, we present an optical projection tomography (OPT) method designed for imaging of ...

Optical Soc Amer2017