Publications de Marcos Penedo Garcia

Significant reduction of cell invasiveness in nanoneedle insertion into a living cell with an electron-beam-deposited probe: impacts of probe geometry, speed and vibration

Intracellular probing of living cells using atomic force microscopy (AFM) has advanced significantly, but it requires specially designed nanoprobes to achieve precision and minimize damage. The development of focused ion beam (FIB)-milled nanoprobes enable ...

2025

Controlled Sensing of User-Defined Aptamer-Based Targets Using Scanning Ionic Conductance Spectroscopy

Aleksandra Radenovic, Georg Fantner, Lely Feletti, Marcos Penedo Garcia, Wayne Yang Wen Wei, Barney Frederick Drake, Helena Miljkovic, Zahra Ayar Dulabi

Solid-state nanopores offer the possibility of detecting disease biomarkers in early diagnostic applications. Standard approaches harness fingerprinting, where protein targets are bound to DNA carriers and detected in free translocation with a solid-state ...

2025

Deep learning for enhancement of low-resolution and noisy scanning probe microscopy images

Georg Fantner, Marcos Penedo Garcia

In this study, we employed traditional methods and deep learning models to improve resolution and quality of low-resolution AFM images made under standard ambient scanning. Both traditional methods and deep learning models were benchmarked and quantified r ...

Beilstein Institut2025

Antimicrobial peptides selectively target malaria parasites by a cholesterol-dependent mechanism

Georg Fantner, Marcos Penedo Garcia, Navid Asmari Saadabad

Hundreds of thousands die annually from malaria caused by Plasmodium falciparum (Pf), with the emergence of drug-resistant parasites hindering eradication efforts. Antimicrobial peptides (AMPs) are known for their ability to disrupt pathogen membranes with ...

2025

Enhanced feedback performance in off-resonance AFM modes through pulse train sampling

Georg Fantner, Marcos Penedo Garcia, Navid Asmari Saadabad, Santiago Harald Andany, Mustafa Kangül

Dynamic atomic force microscopy (AFM) modes that operate at frequencies far away from the resonance frequency of the cantilever (off-resonance tapping (ORT) modes) can provide high-resolution imaging of a wide range of sample types, including biological sa ...

Beilstein-Institut2024

Deterministic grayscale nanotopography to engineer mobilities in strained MoS2 FETs

Jürgen Brugger, Nicola Marzari, Andras Kis, Giovanni Boero, Georg Fantner, Xia Liu, Marcos Penedo Garcia, Norma Rivano, Jin Jiang, Berke Erbas

Field-effect transistors (FETs) based on two-dimensional materials (2DMs) with atomically thin channels have emerged as a promising platform for beyond-silicon electronics. However, low carrier mobility in 2DM transistors driven by phonon scattering remain ...

Nature Research2024

High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping

Georg Fantner, Maartje Martina Cornelia Bastings, Bahareh Ghadiani, Marcos Penedo Garcia, Santiago Harald Andany, Cem Tekin, Mustafa Kangül, Veronika Cencen

High-speed atomic force microscopy (HS-AFM) is a popular molecular imaging technique for visualizing single-molecule biological processes in real-time due to its ability to image under physiological conditions in liquid environments. The photothermal off-r ...

Journal Of Visualized Experiments2024

Large-area, self-healing block copolymer membranes for energy conversion

Marcos Penedo Garcia

Membranes are widely used for separation processes in applications such as water desalination, batteries and dialysis, and are crucial in key sectors of our economy and society1. The majority of technologically exploited membranes are based on solid polyme ...

2024

A polymer-semiconductor-ceramic cantilever for high-sensitivity fluidcompatible microelectromechanical systems

Dirk Grundler, Georg Fantner, Nahid Hosseini, Marcos Penedo Garcia, Oliver Peric, Santiago Harald Andany, Matthias Neuenschwander

Active microelectromechanical systems (MEMS) with integrated electronic sensing and actuation can provide fast and sensitive measurements of force, acceleration and biological analytes. Strain sensors integrated onto MEMS cantilevers are widely used to tra ...

Springer Science and Business Media LLC2024

Revealing the Mechanism Underlying 3D-AFM Imaging of Suspended Structures by Experiments and Simulations

Marcos Penedo Garcia

The invention of 3D atomic force microscopy (3D-AFM) has enabled visualizing subnanoscale 3D hydration structures. Meanwhile, its applications to imaging flexible molecular chains have started to be experimentally explored. However, the validity and princi ...

Wiley-V C H Verlag Gmbh2024