The invention discloses a method for the manuf. of a peptidic folding precursor (switch-peptide) stable and sol. at physiol. conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is to provide a tool for the quant., controlled in vitro study of fibrillogenesis and its inhibition of peptides involved in degenerative diseases. Prepn. of peptides is described.
Herbert Shea, Vito Cacucciolo, Krishna Manaswi Digumarti
Jérôme Baudry, Ion-Gabriel Mihailescu