Ni-Catalyzed Cross Coupling of Non-Activated and Functionalized Alkyl Halides with Alkyl Grignard Reagents
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An efficient asym. synthesis of (2S,3S)-beta -hydroxyleucine is described. The key step in the synthesis was a highly diastereoselective nucleophilic addn. of Grignard reagent to N,N-dibenzyl-O-TBS-serinal (TBS = SiMe2CMe3). This strategy should be applica ...
Ni-catalyzed Sonogashira coupling of nonactivated, β-H- containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl h ...
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