A method for removal of N-Boc protecting groups from substrates on TFA-sensitive resins

N-tert-butyloxycarbonyl (Boc) groups can be removed from peptides supported on Rink's amide resin by treatment with trimethylsilyl triflate/2,6-lutidine. This methodol. was illustrated here with syntheses of several peptides, but it is likely to be used more extensively in solid phase syntheses of small mol. libraries. [on SciFinder (R)]