Bioresorbable Nanocomposite Foams for Bone Tissue Engineering
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The mechanical properties of healthy and diseased bone tissue are extensively studied in mechanical tests. Most of this research is motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged. ...
The aim of this investigation was to test the biocompatibility of three-dimensional bioresorbable foams made of poly(L-lactic acid) (PLA), alone or filled with hydroxyapatite (HA) or beta-tricalcium phosphate (beta-TCP), with human primary osteoblasts, usi ...
In an attempt to increase the life of cementless prostheses, an hydroxyapatite-coated implant which releases a bisphosphonate has been suggested as a drug-delivery system. Our in vitro study was designed to determine the maximum dose to which osteoblasts c ...
In current biological and biomedical research, quantitative endpoints have become an important factor of success. Classically, such endpoints were investigated with 2D imaging, which is usually destructive and the 3D character of tissue gets lost. 3D imagi ...
Owing to its porous cellular structure and polymeric components, wood can be easily shaped in its transversal direction when it is heated and has sufficient water content. Thanks to this thermohydrous behaviour many manufacturing processes such as densific ...
Bone is a natural cellular composite, with a gradient structure going from a loose interconnected core to an outer dense wall, thus minimising bone weight while maintaining a high mechanical performance. Bone can be repaired using either auto- or allo- gra ...
Early detection of white matter lesions in childhood-onset cerebral adrenoleukodystrophy (ALD) is important as hematopoietic cell transplantation (HCT), currently the only effective treatment, is beneficial only if performed early in the disease course. ...
OBJECTIVE: We hypothesized that bone mineral density increase following bisphosphonates treatments may be explained by the influence of the drug on the mechanical bone remodeling parameters. BACKGROUND: Patients treated with bisphosphonates continuously in ...
Total Hip Replacement (THR) is today a routine procedure executed more than 800'000 times per year worldwide. THR gives generally satisfactory results, although the quality of outcome is inversely proportional to the age of the patient. In parallel, there ...
In recent years, the important role of the organic matrix for the mechanical properties of bone has become increasingly apparent. It is therefore of great interest to understand the interactions between the organic and inorganic constituents of bone and le ...
