Publication
Localized in vivo hyperpolarization transfer sequences
Publications associées (32)
Diffusion-weighted MRS of acetate in the rat brain
Rolf Gruetter, Bernard Lanz, Hikari Ananda Infinity Yoshihara, Nicolas Kunz, Masoumeh Dehghani Moghadam
Acetate has been proposed as an astrocyte-specific energy substrate for metabolic studies in the brain. The determination of the relative contribution of the intracellular and extracellular compartments to the acetate signal using diffusion-weighted magnet ...
Wiley-Blackwell2017Proton diffusion spectroscopy and modeling of brain metabolism at 14.1T
As a field at the CIBM, Nuclear magnetic resonance (NMR)spectroscopy can be applied non-invasively to explore the metabolic fate of energy fuel substrates, as well as the rate at which they are consumed, using 13C and 1H nuclei. The work of this thesis enc ...
EPFL2016Nuclear overhauser spectroscopy of chiral CHD methylene groups
Geoffrey Bodenhausen, Fabien Ferrage
Nuclear magnetic resonance spectroscopy (NMR) can provide a great deal of information about structure and dynamics of biomolecules. The quality of an NMR structure strongly depends on the number of experimental observables and on their accurate conversion ...
Springer Verlag2016Optimizing dissolution dynamic nuclear polarization
This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified ...
Academic Press Inc Elsevier Science2016Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance
Rolf Gruetter, Hongxia Lei, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen
BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...
Elsevier2015Optimal pathway reconstruction on 3D NMR maps
A three-dimensional Nuclear Magnetic Resonance (NMR) map displays the results of NMR experiments, that allow to determine the shape of a biological molecule. Shape calculation starts from a reconstruction of a sequence of NMR signals, which is equivalent t ...
Elsevier Science Bv2015Method for nuclear magnetic resonance (NMR) spectroscopy measurements using long-lived coherences (LLC)
Geoffrey Bodenhausen, Paul Romeo Vasos, Riddhiman Sarkar, Puneet Ahuja
A method for nuclear magnetic resonance (NMR) spectroscopy of a sample comprises preparation of the sample and carrying out an NMR spectroscopy measurement. Preparation includes excitation of long lived coherences (LLC) between the singlet state S0 and the ...
2013Decoupling of Magnetic Resonance Signals in Time and Frequency Domain
Nuclear magnetic resonance (NMR) was discovered in the first half of the 20th century. Today, neither analytical chemistry without NMR spectroscopy nor medical diagnostics without magnetic resonance imaging (MRI) could be imagined. A magnetic resonance sig ...
EPFL2013Methods for Molecular Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy using Hyperpolarized Nuclei
Since the introduction 10 years ago of the dissolution method, Dynamic Nuclear Polarization (DNP) became a widely applied and powerful technique to enhance nuclear magnetic resonance (NMR) signals of low naturally abundant, insensitive nuclear spins for an ...
EPFL2013In vivo metabolic studies in skeletal and cardiac muscle using ¹³C magnetic resonance spectroscopy
Josefina Adriana Maria Bastiaansen
Cardiac and skeletal muscle function relies on a continuous energy production via fatty acid metabolism and mitochondrial oxidation of pyruvate, with a fine balance between substrate delivery and utilization. Changes in metabolism are increasingly being im ...
EPFL2013