Publication

Liver fibrosis: non-invasive assessment with MR elastography

Publications associées (86)

1H MRS to investigate the hepatic profile of GLUT2-/- mice

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

We performed 1H MRS at 14.1T in the liver of GLUT2-/- and wild-type (WT) mice. Improved spectral resolution allowed identifying peaks from the lipid resonances, choline containing compounds, taurine and glycogen in WT mice. Performing the same measurements ...

2014

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

Johan Auwerx, Dongryeol Ryu, Eija Riitta Pirinen

No therapy for non-alcoholic steatohepatitis (NASH) has been approved so far. Roux-en-y gastric bypass (RYGB) is emerging as a therapeutic option, although its effect on NASH and related hepatic molecular pathways is unclear from human studies. We studied ...

2014

In vivo studies of brain metabolism in animal models of Hepatic Encephalopathy using (1)H Magnetic Resonance Spectroscopy

Cristina Ramona Cudalbu

Hepatic encephalopathy (HE) is a common and severe neuropsychiatric complication present in acute and chronic liver disease. The unique advantages of high field (1)H MRS provide a method for assessing pathogenic mechanism, diagnosis and monitoring of HE, a ...

Springer US2013

The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

Rolf Gruetter, Cristina Ramona Cudalbu, Hongxia Lei, João Miguel das Neves Duarte

C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and ge ...

Public Library of Science2013

In Vivo 1H MRS at 14.1T for the Accurate Characterization of the Lipid Profile of the Mouse Liver

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

1H MRS was employed at 14.1T to non-invasively quantify the lipid content of small samples (8-15 µl). In the mouse liver, good spectral stability was achieved by running individual scans within one breathing cycle. Ultra short TE STEAM with water suppressi ...

2013

Towards higher precision in instrument guided liver surgery: automatic registration of 3D ultrasound with pre-operative MeVis-CT

Delphine Ribes Lemay, Matthias Peterhans

Purpose Liver cancer is the 5 most common cancer and shows poor prognosis. Surgical removal of liver tumours, the only existing curative treatment, can merely be used in 10-20% of the case. Increasing surgical precision is a key-challenge to give more pati ...

2012

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets

David Michael Suter

Hepatitis C virus (HCV) perturbs the host's lipid metabolism and often results in hepatic steatosis. In nonalcoholic fatty liver disease, the intrahepatic down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical mecha ...

2011

A navigation system for open liver surgery: design, workflow and first clinical applications

Charles Baur, Benoît Dagon, Matthias Peterhans

Background The surgical treatment of liver tumours relies on precise localization of the lesions and detailed knowledge of the patient-speciﬁc vascular and biliary anatomy. Detailed three-dimensional (3D) anatomical information facilitates complete tumour ...

2011

Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems

Kristin Schirmer

In order to monitor potential contamination deriving from exploration and transport of oil in the Urucu region (Brazil), there is a need to establish suitable biomarkers for native Amazonian fish. Therefore. the transcript expression of various potentially ...

2011

IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C

Jacques Fellay

Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with peginterferon-α and ribavirin. We hypothesized ...

2010

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