HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48 HIV-1 amino acid variants (p
Didier Trono, Evaristo Jose Planet Letschert, Wayo Matsushima
Jacques Fellay, Bruno Emanuel Ferreira De Sousa Correia, Andreas Scheck, Olivier Noël Marie Naret, Arne Schneuing, David Gfeller, Thomas Junier, Zhi Ming Xu, Dylan Lawless, Sina Rüeger
Tamar Kohn, Xavier Fernandez Cassi