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Fast Resonance Assignment and Fold Determination of Human Superoxide Dismutase by High-Resolution Proton-Detected Solid-State MAS NMR Spectroscopy

Publications associées (46)

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Slow dynamic processes, such as biomolecular folding/unfolding, macromolecular diffusion, etc., can be conveniently monitored by solution-state two-dimensional (2D) NMR spectroscopy, provided the inverse of their rate constants does not exceed the nuclear ...

EPFL2010

Determination of the antisymmetric part of the chemical shift anisotropy tensor via spin relaxation in nuclear magnetic resonance

Geoffrey Bodenhausen

Relaxation processes induced by the antisymmetric part of the chemical shift anisotropy tensor (henceforth called anti-CSA) are usually neglected in NMR relaxation studies. It is shown here that anti-CSA components contribute to longitudinal relaxation rat ...

American Institute of Physics2010

Search for nuclear magnetic resonance evidence of spin accumulation

Aurore Rudolf

Developments towards an understanding of the nature of conductance at the interface between two different metallic layers – ferromagnetic and non magnetic – as well as the discovery of giant magnetoresistance have stirred attention from both the scientific ...

EPFL2009

Nuclear magnetic resonance (NMR) spectroscopy can be applied in vivo to measure static or dynamic biochemical information, e.g., concentrations of metabolites and metabolic fluxes, using various nuclei such as 1H, 13C, 31P and 15N. The work of this thesis ...

EPFL2009

Proton NMR of15N-choline metabolites enhanced by dynamic nuclear polarization

Rolf Gruetter, Geoffrey Bodenhausen, Arnaud Comment, Sami Jannin, Paul Romeo Vasos, Riddhiman Sarkar

(Figure Presented) Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo, magnetization can be enhanced by dynamic nuclear polarization (DNP). We have hyperp ...

2009

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

Hilal Lashuel, Bruno Claude Daniel Fauvet, Magdalena Zweckstetter, Hajer Ouertatani-Sakouhi, Farah El Turk

Macrophage migration inhibitory factor (MIF) is a homotrimeric multifunctional proinflammatory cytokine that has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. Current therapeutic strategies for targeting MIF focus on ...

American Chemical Society2009

NMR-spectroscopic characterization of phosphodiester bond cleavage catalyzed by the minimal hammerhead ribozyme

Philipp Wenter

In order to relate the conformational dynamics of the hammerhead ribozyme to its biological function the cleavage reaction catalyzed by the hammerhead ribozyme was monitored by time-resolved nuclear magnetic resonance (NMR) spectroscopy. For this purpose, ...

2008

We show that the prediction of N-15 relaxation rates in proteins can be extended to systems with anisotropic global, rotational diffusion by using a network of coupled rotators (NCR), starting from a three-dimensional structure. The relaxation rates predic ...

Wiley-Blackwell2008

Three-dimensional nuclear magnetic resonance (3D NMR) provides one of the foremost analytical tools available for the elucidation of biomolecular structure, function and dynamics. Executing a 3D NMR experiment generally involves scanning a series of time-d ...

2007

A detailed characterization of the time scales and mechanisms by which RNA molecules change their folding structure upon binding of metabolites or during catalysis is important for the understanding of the different biological functions of RNA. The folding ...

EPFL2006