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The present invention provides methods of increasing muscle mass and muscle miochodrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic ...
Flexoelectricity-the coupling between polarization and strain gradients-is a universal effect allowed by symmetry in all materials. Following its discovery several decades ago, studies of flexoelectricity in solids have been scarce due to the seemingly sma ...
Neurodegenerative diseases are generally characterized by the selective degeneration of particular neuronal populations and the accumulation of abnormal or aggregated proteins within, but occasionally external to, neurons in affected brain regions. These d ...
The Human Brain Project (HBP) is a candidate project in the European Union's FET Flagship Program, funded by the ICT Program in the Seventh Framework Program. The project will develop a new integrated strategy for understanding the human brain and a novel ...
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The existence of a length threshold, of about 35 residues, above which polyglutamine repeats can give rise to aggregation and to pathologies, is one of the hallmarks of polyglutamine neurodegenerative diseases such as Huntington's disease. The reason why s ...
The present invention relates to new 2-piperazin-1-yl-4H-1,3-benzothiazin- 4-one derivatives and their use for the treatment of mammalian infections caused by bacteria, especially diseases like tuberculosis (TB), Buruli ulcer and leprosy that result from i ...
The present invention relates to novel organometallic compds. for use as a medicine, in particular in photodynamic therapy against various diseases, such as cancer. The compds. comprise a central porphyrin or phthalocyanine backbone to which ligand linkers ...
The correlation between neurodegenerative disease and protein aggregation in the brain has long been recognized, but a causal relationship has not been unequivocally established, in part because a discrete pathogenic aggregate has not been identified. The ...
Human behaviour plays an important role in the spread of infectious diseases, and understanding the influence of behaviour on the spread of diseases can be key to improving control efforts. While behavioural responses to the spread of a disease have often ...
When, where and how is the head-tail axis of the embryo set up during development? These are such fundamental and intensely studied questions that one might expect them to have been answered long ago. Not so; we still understand very little about the cellu ...