Publication
Acetylated tubulin is essential for touch sensation in mice
Publications associées (34)
Hydraulically Amplified Electrostatic Taxels (HAXELs) for Full Body Haptics
Herbert Shea, Edouard Franck Vincent Gustave Leroy
The ability to mechanically stimulate touch receptors over the entire body is a key feature for fully immersive and highly realistic virtual reality experience. Haptic stickers, flexible arrays of HAXELs (hydraulically amplified TAXels), that enable cutane ...
WILEY2023Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas
An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...
EPFL2023Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination
Pierre Gönczy, Beat Fierz, Luc Reymond, Georgios Hatzopoulos, Cédric Pourroy, Po-Han Chang, Nora Guidotti, Ninad Dilip Agashe, Timothy Matthias Reichart, Eduard Hubert Theodoor Marius Ebberink, Fabian Zacharias Schneider
Microtubules, a critical component of the cytoskeleton, carry post-translational modifications (PTMs) that are important for the regulation of key cellular processes. Long-lived microtubules, in neurons particularly, exhibit both detyrosination of a-tubuli ...
NATURE PORTFOLIO2023Neuronal Circuits In Barrel Cortex For Whisker Sensory Perception
The array of whiskers on the snout provides rodents with tactile sensory information relating to the size, shape and texture of objects in their immediate environment. Rodents can use their whiskers to detect stimuli, distinguish textures, locate objects a ...
AMER PHYSIOLOGICAL SOC2021During capsaicin-induced central sensitization, brush allodynia is associated with baseline warmth sensitivity, whereas mechanical hyperalgesia is associated with painful mechanical sensibility, anxiety and somatization
Background Mechanical hyperalgesia and allodynia incidence varies considerably amongst neuropathic pain patients. This study explored whether sensory or psychological factors associate with mechanical hyperalgesia and brush allodynia in a human experimenta ...
WILEY2021Anatomical and functional characterization of neocortical circuits involved in transforming whisker sensory processing into goal-directed licking
The choice of an action upon perception of an external stimulus, arriving at a sensory organ of an animal, depends on previous experiences and outcomes throughout its life. In the rodent brain, the underlying mechanisms involved in simple sensorimotor tran ...
EPFL2021Combining Reflexes and External Sensory Information in a Neuromusculoskeletal Model to Control a Quadruped Robot
Auke Ijspeert, Azhar Aulia Saputra
This article examines the importance of integrating locomotion and cognitive information for achieving dynamic locomotion from a viewpoint combining biology and ecological psychology. We present a mammalian neuromusculoskeletal model from external sensory ...
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021Task-driven hierarchical deep neural network models of the proprioceptive pathway
Alexander Mathis, Mackenzie Mathis, Kai Jappe Sandbrink, Matthias Bethge, Pranav Mamidanna
Biological motor control is versatile and efficient. Muscles are flexible and undergo continuous changes requiring distributed adaptive control mechanisms. How proprioception solves this problem in the brain is unknown. Here we pursue a task-driven modelin ...
Neuroscience2020Sensorimotor processing in the rodent barrel cortex
Tactile sensory information from facial whiskers provides nocturnal tunnel-dwelling rodents, including mice and rats, with important spatial and textural information about their immediate surroundings. Whiskers are moved back and forth to scan the environm ...
NATURE PUBLISHING GROUP2019Protein Engineering Tools to Explore the Function of Protein Post-Translational Modifications for Chromatin and Microtubule Cytoskeletal Biology
Protein post-translational modifications (PTMs) play a crucial role in expanding the protein diversity and are one of the major mechanisms through which cells respond to ever changing environmental cues. The function of two of the most important cellular c ...
EPFL2019