Mapping the function of neuronal ion channels in model and experiment
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Two channels were observed in extracts of whole Mycobacterium bovis BCG cells using organic solvents and detergents. The channels derived from organic solvent treatment had a single-channel conductance of about 4.0 nS in 1 M KCl in lipid bilayer membranes ...
Gating of an artificial receptor was monitored for the first time by impedance spectroscopy in tethered lipid bilayer. Subnanomolar concns. of antibody were detected by modulation of the channel activity. The principle of gating by an antibody is particula ...
The functional anal. of single ion channel proteins presents a serious bottleneck in the process of finding new pharmacol. active compds. Currently available single channel recording methods are not suited for automation and miniaturization. However, new t ...
A method is presented to form gold-electrode-tethered lipid bilayers with exceptionally high elec. resistances. Elec. impedance spectroscopy is used to monitor the bilayer incorporation of a ligand-gated ion channel protein and the modulation of its channe ...
The authors probed the function of receptor protein OmpF by in situ measurement of both the binding of ligands by surface plasmon resonance (SPR) and subsequent changes of the channel activity by impedance spectroscopy (IS). [on SciFinder (R)] ...
All biol. ion channels are selectively permeable to specific ions. This mechanism needs to be understood in terms of the interaction of the permeating ions with the surrounding water and protein mols. During the past several years, there have been enormous ...
