Mapping the function of neuronal ion channels in model and experiment
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We developed a new non-invasive integrated microsystem for electrophysiological measurements on Xenopus laevis oocytes. The Xenopus oocyte is a well-known expression system for various kinds of ion channels that are of potential interest for drug screening ...
Burnashev in 1976 gave an exact expression for the reliability function of a discrete memoryless channel (DMC) with noiseless feedback. A coding scheme that achieves this exponent needs, in general, to know the statistics of the channel. Suppose now that t ...
Communication over unknown discrete memoryless channels with instantaneous and perfect feedback is considered. For a given set of channels we define a notion of optimal coding schemes in terms of achievable rate and error exponent, and prove the existence ...
Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...
Communication over unknown discrete memoryless channels with instantaneous and perfect feedback is considered. For a given set of channels we define a notion of optimal coding schemes in terms of achievable rate and error exponent, and prove the existence ...
The subject of this thesis is the study of the structure and function of the human muscle nicotinic acetylcholine receptor (nAChR), which is a typical member of the large class of ligand-gated ion channels. Appropriate techniques, like site-directed mutage ...
The thesis presented here describes studies of ligand binding, function, and arrangement of ligand-gated ion channels in cell membranes. Fluorescence microscopy and the patch clamp technique are used to investigate the nicotinic acetylcholine receptor and ...
The computational power of the neocortex arises from interactions of multiple neurons, which display a wide range of electrical properties. The gene expression profiles underlying this phenotypic diversity are unknown. To explore this relationship, we comb ...
The estimation of doubly-selective channels is challenging since long channel impulse response should be estimated with a fast tracking speed. Provided that a structure of the channel response is sparse, i.e., only a few of channel gains are nonzero, a tra ...
An apparatus for manipulating fluid samples comprises a micro-chip device having first and second covered channels, each channel having openings at both ends. The channels intersect to form a common intersection. Three of the openings of the channels are c ...
