Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe
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Background and aims - Recent methodological and theoretical advances in community ecology have allowed more robust exploration of complementary facets of biodiversity in plant communities. Focusing on semi-natural permanent grasslands of the French Jura Mo ...
National Botanic Garden of Belgium and Royal Botanical Society of Belgium2014
Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on t ...
Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral particles from infected cells. However, the IAV ...
We present a descriptive analysis of Twitter data. Our study focuses on extracting the main side effects associated with HIV treatments. The crux of our work was the identification of personal tweets referring to HIV. We summarize our results in an infogra ...
The impact of host genetic variation on determining the differential outcomes after HIV infection has been studied by two approaches: targeting of candidate genes and genome-wide association studies (GWASs). The overlap in genetic variants that has been id ...
Background and aims - Recent methodological and theoretical advances in community ecology have allowed more robust exploration of complementary facets of biodiversity in plant communities. Focusing on semi-natural permanent grasslands of the French Jura Mo ...
In ecology, "disease tolerance" is defined as an evolutionary strategy of hosts against pathogens, characterized by reduced or absent pathogenesis despite high pathogen load. To our knowledge, tolerance has to date not been quantified and disentangled from ...
HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at increasing transcription of the latent provirus. In the present study we observed that latently infected CD4+ T cells from HIV-infected individuals failed to pr ...
Background: Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential ro ...
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence ...