Study of fast exchanging processes by NMR Spectroscopy
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By implementing new NMR methods that were designed to map very slow exchange processes we have investigated and characterized the refolding kinetics of a thermodynamically stable 34mer RNA sequence in dynamic equilibrium. The RNA sequence was designed to u ...
We report site-resolved observation of hydrogen exchange in the micro-crystalline protein Crh. Our approach is based on the use of proton T-2(')-selective H-1-C-13-C-13 correlation spectra for site-specific assignments of carbons nearby labile protein prot ...
The heterotritopic ligand [bpy(DTTA)2]8- has two diethylenediamine-tetraacetate units for selective lanthanide(III) coordination and one bipyridine function for selective FeII coordination. In aqueous solution and in the presence of these metals, the ligan ...
Since many biological processes occur on the μs to ms time scale, internal dynamics on that time scale is believed to be related to biological functionality. The characterization of internal dynamics is thus an important issue to improve our understanding ...
Cylindramide (I) was built up from three components: a hydroxyornithine deriv. II, a tetrazolylsulfone III, and a substituted pentalene subunit IV. Deriv. II was prepd. in a six-step reaction sequence involving the Wittig reaction and a Sharpless asym. dih ...
Proton-observed carbon-edited (POCE) NMR spectroscopy is commonly used to measure 13C labeling with higher sensitivity compared to direct 13C NMR spectroscopy, at the expense of spectral resolution. For weakly coupled first-order spin systems, the multiple ...
The inability to determine molecular structures from powdered samples is a key barrier to progress in many areas of molecular and materials science. We report an approach to structure determination that combines molecular modeling with experimental spin di ...
Delayed-acquisition methods, namely, echo and constant-time-acquisition approaches, allow a significant improvement in resolution in the proton solid state NMR spectra of surface organometallic catalysts such as [ syn-( SiO) Mo-( =NAr)( =(CHBu)-Bu-t)( (CH2 ...
Water-protein interactions play a major role in protein folding, structure, and function, and solid-state NMR has recently been shown to be a powerful tool for the site-resolved observation of these interactions in solid proteins. In this article we report ...
Scalar (J) couplings in solid-state NMR spectroscopy are sensitive to covalent through-bond interactions that make them informative structural probes for a wide range of complex materials. Until now, however, they have been generally unsuitable for use in ...
