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Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Publications associées (45)

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Common Mechanisms for Calorie Restriction and AC5 Knockout Models of Longevity

Johan Auwerx

Adenylyl cyclase type 5 knockout mice (AC5 KO) live longer and are stress resistant, similar to calorie restriction (CR). AC5 KO mice eat more, but actually weigh less and accumulate less fat compared to WT mice. CR applied to AC5 KO result in rapid decrea ...

Wiley-Blackwell2012

By improving spatial and anatomical specificity, localized spectroscopy can enhance the power and accuracy of the quantitative analysis of cellular metabolism and bioenergetics. Localized and nonlocalized dynamic 31P magnetic resonance spectroscopy using a ...

Wiley-Blackwell2012

Formation and Optogenetic Control of 3D Engineered Skeletal Muscle Bioactuators

Mahmut Selman Sakar

Densely arrayed skeletal myotubes are activated individually and as a group using precise optical stimulation with high spatiotemporal resolution. Skeletal muscle myoblasts are genetically encoded to express a light-activated cation channel, Channelrhodops ...

Royal Society of Chemistry2012

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Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enha ...

2011

Muscle lengths and moment arms during activities of daily living

Markus Jürgen Heidl

Muscle lengths and moment arms are important parameters of musculoskeletal models. These data determine muscle forces and moments and thus joint contact forces, an important value in musculoskeletal biomechanics. In the literature, there are many data avai ...

2011

Leukocyte-endothelial cell interaction is necessary for photodynamic therapy induced vascular permeabilization

Hubert van den Bergh, Elodie Debefve, Hans-Anton Lehr

Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investig ...

2011

A new method to measure local oxygen consumption in human skeletal muscle during dynamic exercise using near-infrared spectroscopy

Dimitri Nestor Alice Van De Ville

Near infrared spectroscopy (NIRS) can readily report on changes in blood volume and oxygenation. However, it has proved more problematic to measure real-time changes in blood flow and oxygen consumption. Here we report the development of a novel method usi ...

Institute of Physics2010

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5)

Dimitri Nestor Alice Van De Ville, Theo Lasser, Kai Johnsson, Marcel Leutenegger, Boris Hinz, Iwan Märki, Thiemo Spielmann, Aurélie Formey de Saint Louvent

The measurement of tissue and cell oxygenation is important for understanding cell metabolism. We have addressed this problem with a novel optical technique, called triplet imaging, that exploits oxygen-induced triplet lifetime changes and is compatible wi ...

Elsevier2010

Is migraine a lateralization defect?

Nouchine Hadjikhani

Migraine often co-occurs with patent foramen ovale (PFO), and some people have suggested surgical closure as an efficient treatment for migraine. Prospective studies, however, do not report radical effect of PFO surgery on migraine. Here, we examined the h ...

Lippincott, Williams & Wilkins2008

Using Monte Carlo simulations for a semi-infinite medium representing a skeletal muscle tissue, it is demonstrated that the zero- and first-order moments of the power spectrum for a representative pixel of a full-field laser-Doppler imager behave different ...

IOP2008