Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling
Publications associées (36)
Graph Chatbot
Chattez avec Graph Search
Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.
AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.
Abstract The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-in ...
Defects play a critical role in the dynamic fragmentation process of structural ceramics. Cracks initiate at seemingly random locations, propagate and coalesce to form fragments. The process is accompanied by stress release waves, whose influence is diffic ...
Pygopus has been discovered as a fundamental Wnt signaling component in Drosophila. The mouse genome encodes two Pygopus homologs, Pygo1 and Pygo2. They serve as context-dependent beta-catenin coactivators, with Pygo2 playing the more important role. All P ...
Roebel cables are one possible option for use in the manufacture of high current conductors for various technical applications. In this work the behaviour of critical current under transverse loads up to 90 MPa was studied in coated conductor Roebel cables ...
During early somite stages of development, the broad endoderm-derived foregut and hindgut territories become further subdivided along the antero-posterior axis into organs. One of these organs is the pancreas which serves two major physiological functions: ...
The Notch signaling pathway is an important contributor to the development and homeostasis of the cardiovascular system. Not surprisingly, mutations in Notch receptors and ligands have been linked to a variety of hereditary diseases that impact both the he ...
In this thesis, we present a new approach to integrating software system defect data: Defect reports, code reviews and code commits. We propose to infer defect types by keywords. We index defect reports into groups by the keywords found in the descriptions ...
For electronic transport at the nanoscale, coherent scattering at defects plays an important role. Therefore, the capability of visualizing the influence of defects on the conductivity of single atomic junctions may benefit the development of future nano-e ...
Through first-principles simulation methods, we assign the origin of Fermi-level pinning at GaAs surfaces and interfaces to the bistability between the As-As dimer and two As dangling bonds, which transform into each other upon charge trapping. This defect ...