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Wearable devices are an unobtrusive, cost-effective means of continuous ambulatory monitoring of chronic cardiovascular diseases. However, on these resource-constrained systems, electrocardiogram (ECG) processing algorithms must consume minimal power and memory, yet robustly provide accurate physiological information. This work presents REWARD, the Relative-Energy-based WeArable R-Peak Detection algorithm, which is a novel ECG R-peak detection mechanism based on a nonlinear filtering method called Relative-Energy (Rel-En). REWARD is designed and optimized for real-time execution on wearable systems. Then, this novel algorithm is compared against three state-of-the-art real-time R-peak detection algorithms in terms of accuracy, memory footprint, and energy consumption. The Physionet QT and NST Databases were employed to evaluate the algorithms’ accuracy and robustness to noise, respectively. Then, a 32-bit ARM Cortex-M3-based microcontroller was used to measure the energy usage, computational burden, and memory footprint of the four algorithms. REWARD consumed at least 63% less energy and 32% less RAM than the other algorithms while obtaining comparable accuracy results. Therefore, REWARD would be a suitable choice of R-peak detection mechanism for wearable devices that perform more complex ECG analysis, whose algorithms require additional energy and memory resources.