Fast high-resolution brain metabolite mapping on a clinical 3T MRI by accelerated H-1-FID-MRSI and low-rank constrained reconstruction

Purpose: Epitomizing the advantages of ultra short echo time and no chemical shift displacement error, high-resolution-free induction decay magnetic resonance spectroscopic imaging (FID-MRSI) sequences have proven to be highly effective in providing unbiased characterizations of metabolite distributions. However, its merits are often overshadowed in high-resolution settings by reduced signal-to-noise ratios resulting from the smaller voxel volumes procured by extensive phase encoding and the related acquisition times. Methods: To address these limitations, we here propose an acquisition and reconstruction scheme that offers both implicit dataset denoising and acquisition acceleration. Specifically, a slice selective high-resolution FID-MRSI sequence was implemented. Spectroscopic datasets were processed to remove fat contamination, and then reconstructed using a total generalized variation (TGV) regularized low-rank model. We further measured reconstruction performance for random under-sampled data to assess feasibility of a compressed-sensing SENSE acceleration scheme. Performance of the lipid suppression was assessed using an ad hoc phantom, while that of the low-rank TGV reconstruction model was benchmarked using simulated MRSI data. To assess real-world performance, 2D FID-MRSI acquisitions of the brain in healthy volunteers were reconstructed using the proposed framework. Results: Results from the phantom and simulated data demonstrate that skull lipid contamination is effectively removed and that data reconstruction quality is improved with the low-rank TGV model. Also, we demonstrated that the presented acquisition and reconstruction methods are compatible with a compressed-sensing SENSE acceleration scheme. Conclusions: An original reconstruction pipeline for 2D H-1-FID-MRSI datasets was presented that places high-resolution metabolite mapping on 3T MR scanners within clinically feasible limits.

Data-driven Measurement Designs for Magnetic Resonance Imaging

Baran Gözcü

Despite being a powerful medical imaging technique which does not emit any ionizing radiation, magnetic resonance imaging (MRI) always had the major problem of long scanning times that can take up to an hour depending on the application. It also requires uncomfortable breath-holds due to the slow acquisition, sedation of children and repeated scans in the cases of degraded image quality due to body motion. Recent years have seen new image reconstruction techniques that need less amount of acquired data (i.e., accelerated scans) for reconstructing MRI images: parallel imaging and compressed sensing (CS). Although much work has been done on the reconstruction side, there has been relatively less work on experimental design, i.e., which parts of the Fourier domain to acquire during the scan, an essential factor that considerably affects the performance of image reconstructions. The state-of-the-art experimental designs use random subsampling either based on parametric models or heuristical adaptive models. The requirement of extensive parameter tuning and the random nature of the performance render these methods impractical and unreliable for clinical use. Can we systematically use the data acquired during past MRI scans for the design of accelerated scans with a reliable image quality? This problem is the focus of this thesis which proposes a data-driven scan design approach and training procedures which efficiently and effectively learn the structure inherent in the data, and accordingly, design the scans that directly acquire only the most relevant information during acquisition given an acceleration rate constraint. As a result, this boosts the performance of the existing state-of-the-art compressive sensing techniques on real-world datasets. Moreover, this approach provides strong theoretical guarantees by using tools from statistical learning theory. The intensive computational training procedures of our approach are made feasible by large-scale implementations on a parallel computing cluster. In return, this approach avoids any dependence on parametric or heuristic models and provides a reliably consistent image reconstruction performance for accelerated scans. Our approach is flexible and capable of giving deterministic scan designs specific to the anatomy, to the acceleration rate in use, to the reconstruction algorithm and the scan settings such as static/dynamic and parallel imaging. Apart from measurement designs for MRI, this thesis also considers the reconstruction problem. In particular, we focus on the inverse problems that involve a mixture of regularizers in the objective function, exploiting multiple structures at the same time. For these problems, we propose a reliable and systematic optimization framework and illustrate its effectiveness. Finally, in the last part of the thesis, we present a data-driven model and an optimization method for the design of nearly isometric, linear and dimensionality reducing embeddings.

EPFL2019

Data-driven Measurement Designs for Magnetic Resonance Imaging

Baran Gözcü

EPFL2019