Publications associées à New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

Cryo-EM structure of alpha-synuclein fibrils

Henning Paul-Julius Stahlberg, Ricardo Cesar Guerrero Ferreira

Parkinson's disease is a progressive neuropathological disorder that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found at abnormally high concentrations in affected neurons. Its hallmark are intracellular inclusions c ...

eLife Sciences Publications, Ltd2018

Miniaturized Sample Preparation for Transmission Electron Microscopy

Henning Paul-Julius Stahlberg, Anastasia Syntychaki

Due to recent technological progress, cryo-electron microscopy (cryo-EM) is rapidly becoming a standard method for the structural analysis of protein complexes to atomic resolution. However, protein isolation techniques and sample preparation methods for E ...

MyJove Corporation2018

Effects of Kr and Xe ion irradiation on the structure of Y2O3 nanoprecipitates in YBCO thin film conductors

Philippe Buffat, Elena Suvorova Buffat

The response of Y2O3 nanoprecipitates in a 1-mu m YBa2Cu3O7-x layer from a superconducting wire Ag/YBCO/buffer metal oxides/Hastelloy to 107 MeV Kr and 167 MeV Xe ion irradiation was investigated using a combination of transmission electron microscopy, dif ...

2018

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

Hilal Lashuel, Juan Kiwi, Bruno Claude Daniel Fauvet, Anass Chiki, Farah El Turk

Intracellular deposits of α-synuclein in the form of Lewy bodies are major hallmarks of Parkinson’s disease (PD) and a range of related neurodegenerative disorders. Post-translational modifications (PTMs) of α-synuclein are increasingly thought to be major ...

2018

Focus: The interface between data collection and data processing in cryo-EM

Henning Paul-Julius Stahlberg

We present a new software package called Focus that interfaces cryo-transmission electron microscopy (cryo-EM) data collection with computer image processing. Focus creates a user-friendly environment to import and manage data recorded by direct electron d ...

Elsevier BV2017

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Hilal Lashuel, Magdalena Zweckstetter, Michael Heinrich

α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of α-synuclein are conserved from yeast to man, but the precise underpinnings of th ...

Oxford University Press2017

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

Hilal Lashuel, Bohumil Maco, Abid Oueslati, Mohamed Bilal Fares

Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in ...

Natl Acad Sciences2016

alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Michele Giugliano

Misfolded protein aggregates represent a continuum with overlapping features in neurodegenerative diseases, but differences in protein components and affected brain regions(1). The molecular hallmark of synucleinopathies such as Parkinson's disease, dement ...

Nature Publishing Group2015

Structure analysis of the YBCO layer in Ag/YBCO/metal oxide buffer/Hastelloy composite tape before and after 107 MeV Kr17+ irradiation

Philippe Buffat, Marco Cantoni, Elena Suvorova Buffat

The effects of 107 MeV Kr-84(17+) ion irradiation on YBa2Cu3O7-x-based second-generation coated conductors were investigated using a combination of transmission electron microscopy, diffraction and X-ray energy dispersive spectrometry. Defects 3-5 nm in di ...

Pergamon-Elsevier Science Ltd2014

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New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

Cryo-EM structure of alpha-synuclein fibrils

Miniaturized Sample Preparation for Transmission Electron Microscopy

Effects of Kr and Xe ion irradiation on the structure of Y2O3 nanoprecipitates in YBCO thin film conductors

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

Focus: The interface between data collection and data processing in cryo-EM

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease

alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Structure analysis of the YBCO layer in Ag/YBCO/metal oxide buffer/Hastelloy composite tape before and after 107 MeV Kr17+ irradiation

Graph Chatbot

Chattez avec Graph Search

Cryo-EM structure of alpha-synuclein fibrils

Miniaturized Sample Preparation for Transmission Electron Microscopy

Effects of Kr and Xe ion irradiation on the structure of Y2O3 nanoprecipitates in YBCO thin film conductors

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

Focus: The interface between data collection and data processing in cryo-EM

Structure analysis of the YBCO layer in Ag/YBCO/metal oxide buffer/Hastelloy composite tape before and after 107 MeV Kr17+ irradiation

alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies