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3D Poses Recovery in Single-Particle Cryo-EM from Learned Pairwise Projection Distances

Publications associées (39)

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Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Henning Paul-Julius Stahlberg

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein implicated in the pathogenesis of both familial and sporadic Parkinson's disease (PD), and currently one of the most promising therapeutic targets for drug design in Parkinson's disease. I ...

Springer Nature2017

Proximity Operators for Phase Retrieval

Michaël Unser, Frédéric Courbin, Ferréol Arnaud Marie Soulez

We present a new formulation of a family of proximity operators that generalize the projector step for phase retrieval. These proximity operators for noisy intensity measurements can replace the classical "noise-free" projection in any projection-based alg ...

OSA2016

Complex pattern projection through a multimode fiber

Demetri Psaltis, Christophe Moser, Damien Claude-Marie Loterie, Salma Farahi

Wavefront shaping through multimode fibers has many interesting applications, such as micromanipulation and endoscopy, where the small diameter of fibers is an advantage in terms of miniaturization. However, pattern projection can suffer from deleterious i ...

Spie-Int Soc Optical Engineering2015

Cryo-electron microscopy of membrane proteins

Henning Paul-Julius Stahlberg

Electron crystallography is used to study membrane proteins in the form of planar, two-dimensional (2D) crystals, or other crystalline arrays such as tubular crystals. This method has been used to determine the atomic resolution structures of bacteriorhodo ...

Humana Press2013

4D Cryo-Electron Microscopy of Proteins

Ulrich Lorenz, Giovanni Maria Vanacore

Cryo-electron microscopy is a form of transmission electron microscopy that has been used to determine the 3D structure of biological specimens in the hydrated state and with high resolution. We report the development of 4D cryo-electron microscopy by inte ...

2013

Is EM dead?

Graham Knott

Since electron microscopy (EM) first appeared in the 1930s, it has held centre stage as the primary tool for the exploration of biological structure. Yet, with the recent developments of light microscopy techniques that overcome the limitations imposed by ...

Company Of Biologists Ltd2013

Limiting factors in single particle cryo electron tomography

Henning Paul-Julius Stahlberg

Modern methods of cryo electron microscopy and tomography allow visualization of protein nanomachines in their native state at the nanometer scale. Image processing methods including sub-volume averaging applied to repeating macromolecular elements within ...

Elsevier BV2012

Sparse Approximations Of Protein Structure From Noisy Random Projections

Victor Panaretos, Kjell Konis

Single-particle electron microscopy is a modern technique that biophysicists employ to learn the structure of proteins. It yields data that consist of noisy random projections of the protein structure in random directions, with the added complication that ...

2011

On Random Tomography with Unobservable Projection Angles

Victor Panaretos

We formulate and investigate a statistical inverse problem of a random tomographic nature, where a probability density function on

\mathbb{R}^3

is to be recovered from observation of finitely many of its two-dimensional projections in random and unobserv ...

Institute of Mathematical Statistics2009

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

Lorène Aeschbach, Patrick Fraering, Hua Li

Gamma-secretase, an integral membrane protein complex, catalyzes the intramembrane cleavage of the beta-amyloid precursor protein (APP) during the neuronal production of the amyloid beta-peptide. As such, the protease has emerged as a key target for develo ...

Elsevier2009

On Random Tomography with Unobservable Projection Angles

Victor Panaretos

We formulate and investigate a statistical inverse problem of a random tomographic nature, where a probability density function on

\mathbb{R}^3

is to be recovered from observation of finitely many of its two-dimensional projections in random and unobserv ...

Institute of Mathematical Statistics2009