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Degradation study on molecules released from laser-based jet injector

Christophe Moser, Jan Krizek, Barbora Lavickova
2021
Article
Résumé

Development of needle-free methods to administer injectable therapeutics has been researched for a few decades. We focused our attention on a laser-based jet injection technique where the liquid-jet actuation mechanism is based on optical cavitation. This study investigates the potential damage to therapeutic molecules which are exposed to nanosecond laser pulses in the configuration of a compact laser-based jet injection device. Implementation of a pulsed laser source at 1574 nm wavelength allowed us to generate jets from pure water solutions and circumvent the need to reformulate therapeutics with absorbing dyes. We performed H1-NMR analysis on exposed samples of Lidocaine and δ-Aminolevulinic acid. We made several tests with linear and plasmid DNA to assess the structural integrity and functional potency after ejection with our device. The tests showed no significant degradation or detectable side products, which is promising for further development and eventually clinical applications.

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Concepts associés (32)
Laser à colorant
vignette|316x316px|Gros plan d'un laser à colorant CW de table à base de rhodamine 6G, émettant à 580 nm (jaune). Le faisceau laser émis est visible sous forme de lignes jaunes pâles entre la fenêtre jaune (au centre) et l'optique jaune (en haut à droite), où il se reflète à travers l'image vers un miroir invisible, et revient dans le jet de colorant depuis le coin inférieur gauche. La solution de colorant orange entre dans le laser par la gauche et sort par la droite, toujours brillante de phosphorescence triplet, et est pompée par un faisceau de 514 nm (bleu-vert) provenant d'un laser à argon.
Laser
thumb|250px|Lasers rouges (660 & ), verts (532 & ) et bleus (445 & ). thumb|250px|Rayon laser à travers un dispositif optique. thumb|250px|Démonstration de laser hélium-néon au laboratoire Kastler-Brossel à l'Université Pierre-et-Marie-Curie. Un laser (acronyme issu de l'anglais light amplification by stimulated emission of radiation qui signifie « amplification de la lumière par émission stimulée de radiation ») est un système photonique.
Jet propulsion
Jet propulsion is the propulsion of an object in one direction, produced by ejecting a jet of fluid in the opposite direction. By Newton's third law, the moving body is propelled in the opposite direction to the jet. Reaction engines operating on the principle of jet propulsion include the jet engine used for aircraft propulsion, the pump-jet used for marine propulsion, and the rocket engine and plasma thruster used for spacecraft propulsion.
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