Publication

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Publications associées (61)

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Engineering Stem Cell Self-organization to Build Better Organoids

Matthias Lütolf, Jonathan Brassard

Organoids form through self-organization processes in which initially homogeneous populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern formation and morphogenesis, though the processes controlling this are poorly characte ...

CELL PRESS2019

Here we discuss, how by applying chemical concepts to biological problems, methods have been developed to map spatiotemporal regulation of proteins and small-molecule modulation of proteome signaling responses. We outline why chemical-biology platforms are ...

2019

Distribution of the ribosome associated endonuclease Rae1 and the potential role of conserved amino acids in codon recognition

Jérémie Piton

We recently identified a novel ribonuclease in Bacillus subtilis called Rae1 that cleaves mRNAs in a translation-dependent manner. Rae1 is a member of the NYN/PIN family of ribonucleases and is highly conserved in the Firmicutes, the Cyanobacteria and the ...

TAYLOR & FRANCIS INC2018

Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells

Onur Tidin

Cells live in ever-changing environments, thereby facing a variety of dynamic environmental signals. Environmental stimuli elicit intracellular responses through signaling pathways, which converge on transcriptional activation or repression of target genes ...

EPFL2018

Rae1/YacP, a new endoribonuclease involved in ribosome-dependent mRNA decay in Bacillus subtilis

Jérémie Piton

The PIN domain plays a central role in cellular RNA biology and is involved in processes as diverse as rRNA maturation, mRNA decay and telomerase function. Here, we solve the crystal structure of the Rae1 (YacP) protein of Bacillus subtilis, a founding mem ...

Wiley2017

Big Data of the Past

Frédéric Kaplan, Isabella Di Lenardo

Big Data is not a new phenomenon. History is punctuated by regimes of data acceleration, characterized by feelings of information overload accompanied by periods of social transformation and the invention of new technologies. During these moments, private ...

2017

Mapping the Analogous City

Dario Rodighiero

Re-descriptions: Aldo Rossi’s Architectural Composition. Chair of Architecture and the Public Building, Friday 1 December 2017, Room U 10:45 – 12:30. On the event of the publication in the new issue of OverHolland of the English translation of Ezio Bonfant ...

2017

Radiography appliance comprising a movable arm

Thomas Gabella

The invention relates to a radiography appliance comprising a column and a movable arm mounted such that it slides along the column and rotates about an axis oriented perpendicularly to the main direction of the column, one end of the arm comprising a dete ...

2016

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Priscilla Suhasna Maithili Briquez

Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...

EPFL2016

Uniting Language Embeddings for Fast and Friendly DSLs

Vojin Jovanovic

The holy grail for a domain-specific language (DSL) is to be friendly and fast. A DSL should be friendly in the sense that it is easy to use by DSL end-users, and easy to develop by DSL authors. DSLs can be developed as entirely new compilers and ecosystem ...

EPFL2016