Computational design of vaccine immunogens

Computational protein engineering has enabled the rational design of customized proteins, which has propelled both sequence-based and structure-based immunogen engineering and delivery. By discerning antigenic determinants of viral pathogens, computational methods have been implemented to successfully engineer representative viral strains able to elicit broadly neutralizing responses or present antigenic sites of viruses for focused immune responses. Combined with improvements in customizable nanoparticle design, immunogens are multivalently displayed to enhance immune responses. These rationally designed immunogens offer unique and powerful approaches to engineer vaccines for pathogens, which have eluded traditional approaches.

Computational design of vaccine immunogens

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes