SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice
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Increasing economic development, and growing population, generated during the last decades a very important growth of cities. Urban regions include nowadays more than half of the global population and, by 2030, this proportion is forecasted to increase to ...
A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...
Body mass and composition reflect the combined effects of three processes: energy intake, energy partitioning (storage), and energy expenditure. Energy is released from food as it is combusted to carbon dioxide and water, and is expended as heat and work w ...
This thesis presents a methodology to analyse the integration of heat recovery energy conversion technologies and biorefinery concepts in existing pulp and paper facilities. By using innovative process integration techniques and thermo-economic optimisatio ...
EPFL2009
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Following the pioneering work of the AGS Tokyo half project, a geographical information system has been developed to model the energy requirement of a urban area. The purpose of this platform is to model with sufficient details the energy services requirem ...
2008
raptor is a specific and essential component of mammalian TOR complex 1 (mTORC1), a key regulator of cell growth and metabolism. To investigate a role of adipose mTORC1 in regulation of adipose and whole-body metabolism, we generated mice with an adipose-s ...
A method for the analysis of process energy requirements has been used to identify in an early design stage the potential process retrofit measures in an integrated pulp and paper mill. The minimum energy requirements (MER) of the process were computed by ...
We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expen ...
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon B, resulting in a white adipose tissue knockdown of PPAR ...
Starting with a classical process for producing methanol using the reforming and synthesis steps, a combined approach applying simulation models and a new synthesis strategy, named Effect Modelling and Optimisation (EMO), has been used to optimise the ener ...
