Variants of the gain domain of adhesion g protein-coupled receptors
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Putative intersubunit electrostatic interactions between charged amino acids on the surfaces of the dimer interfaces of leucine zippers (g-e' ion pairs) have been implicated as determinants of dimerization specificity. To evaluate the importance of these i ...
Despite the importance of trafficking for regulating G protein-coupled receptor signaling, for many members of the seven transmembrane helix protein family, such as odorant receptors, little is known about this process in live cells. Here, the complete lif ...
A mutational screen of amino acid residues of hydrogenase maturation protein HypD from Escherichia coli disclosed that seven conserved cysteine residues located in three different motifs in HypD are essential. Evidence is presented for potential functions ...
Coupling of substituted 2-iodoanilines with Me (S)-2-[di(tert-butoxycarbonyl)amino]-5-oxopentanoate, derived from glutamic acid, in DMF in the presence of Pd(OAc)2 and DABCO provides substituted tryptophans in good to excellent yields. [on SciFinder (R)] ...
Ligand-gated ion channels of the Cys loop family are receptors for small amine-contg. neurotransmitters. Charged amino acids are strongly conserved in the ligand-binding domain of these receptor proteins. To investigate the role of particular residues in l ...
A fluorescent unnatural amino acid was introduced biosynthetically at known sites into the G protein-coupled neurokinin (tachykinin) NK2 receptor by suppression of UAG nonsense codons with the aid of a chem. misacylated synthetic tRNA specifically designed ...
A comparative study of the compositional properties of various protein sets from both cellular and viral organisms is presented. Invariants and contrasts of amino acid usages have been discerned for different protein function classes and for different spec ...
The natural beta-amino acid deriv. Boc-Asp-OBn (Boc = Me3CO2C; Bn = CH2Ph), as well as I (R = CH2CH2CO2Bn, CH2OBn; TCE = CH2CCl3) (prepd. from appropriately protected glutamic acid and serine, resp., by Arndt-Eistert homologation), were employed as buildin ...
A general method for understanding the mechanisms of ligand recognition and activation of G protein-coupled receptors has been developed. A study of ligand-receptor interactions in the prototypic seven-transmembrane neurokinin-2 receptor (NK2) using this f ...
A review with 6 refs. of the authors' work in developing a biophys. technique to investigate the structure, function and dynamics of membrane receptors. A fluorescence-based approach has been developed and applied to the prototypic G protein-coupled recept ...
