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Fast and reliable automated synthesis of RNA and partially 2'-O-protected precursors ("caged RNA") based on two novel, orthogonal 2'-O-protecting groups

Publications associées (35)

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Disagreement and fragmentation in growing groups

Jiyong Zhang, Yubo Xie

The arise of disagreement is an emergent phenomenon that can be observed within a growing social group and, beyond a certain threshold, can lead to group fragmentation. To better understand how disagreement emerges, we introduce an analytically tractable m ...

PERGAMON-ELSEVIER SCIENCE LTD2023

RNA-based nanomedicines and their clinical applications

Yi Wang

RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases. These include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), endo ...

Beijing2023

Effect of Different Communication Affordances on the Emergence of Collaboration Strategies in an Online Multiplayer Game

Pierre Dillenbourg, Barbara Bruno, Hala Khodr, Aditi Kothiyal

In a group, the collective dynamics is governed by the inter- actions between individuals, which can manifest differently depending on the available means of communication. In this paper, we compare 3 conditions of communication affordances (global chat, l ...

Springer2022

Synthesis of new 1-Vinyl and 1-Alkynyl Triazenes

Carl Thomas Bormann

The recent discovery of an N2O-based synthesis of triazenes in our group has enabled the synthesis and investigation of 1-alkynyl triazenes. Early studies showed their potential for a functional group tolerant synthesis of 1-vinyl triazenes, which is furth ...

EPFL2022

Efficient Verifiable Delay Functions

Benjamin Pierre Charles Wesolowski

We construct a verifiable delay function (VDF). A VDF is a function whose evaluation requires running a given number of sequential steps, yet the result can be efficiently verified. They have applications in decentralised systems, such as the generation of ...

SPRINGER INTERNATIONAL PUBLISHING AG2019

A finitely presented infinite simple group of homeomorphisms of the circle

Yash Lodha

We construct a finitely presented, infinite, simple group that acts by homeomorphisms on the circle, but does not admit a non-trivial action by C1-diffeomorphisms on the circle. This is the first such example. The group emerges as a group of piecewise proj ...

WILEY2019

On the lifting of the Dade group

Jacques Thévenaz, Caroline Lassueur

For the group of endo-permutation modules of a finite p-group, there is a surjective reduction homomorphism from a complete discrete valuation ring of characteristic 0 to its residue field of characteristic p. We prove that this reduction map always has a ...

2019

Toward a mixed-initiative QA system: from studying predictors in Stack Exchange to building a mixed-initiative tool

Tiziano Piccardi

This article envisions a new customer support solution that merges the efficiency of crowd-based Question and Answer (QA) sites with the effectiveness of traditional customer care services. QA sites use crowdsourcing to solve problems in a very efficient w ...

Academic Press Ltd- Elsevier Science Ltd2017

Thermally induced group effects among energy piles

Lyesse Laloui, Alessandro Francesco Rotta Loria

The behaviour of conventional pile groups (e.g., closely spaced) that are subjected to mechanical loads has been shown to be different than the behaviour of single isolated piles. The so-called group effects are responsible for this behaviour and must be c ...

2017

Group diffusion LMS

Ali H. Sayed, Jie Chen

Considering groups of variables, rather than variables individually, can be beneficial for estimation accuracy if structural relationships between variables exist (e.g., spatial, hierarchical or related to the physics of the problem). Group-sparsity induci ...

IEEE2016