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Spectroscopic optical coherence tomography based on wavelength de-multiplexing and smart pixel array detection

Publications associées (32)

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Significance: Fluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecula ...

Spie-Soc Photo-Optical Instrumentation Engineers2024

Structural and functional brain imaging using extended-focus optical coherence tomography and microscopy

Paul James Marchand

Neuroimaging techniques aim at revealing the anatomy and functional organisation of cerebral structures. Over the past decades, functional magnetic resonance imaging (fMRI) has revolutionized our understanding of human cerebral physiology through its abili ...

EPFL2018

The present disclosure concerns a holographic system or device comprising at least one optical guiding element (100) configured to redirect light incident from a light source (101) to a target interference plane (103), wherein the optical guiding element i ...

2018

Coherent imaging from bacteria to multicellular organisms

Séverine Coquoz

Structural and functional imaging of cells, tissues and organisms is crucial for understanding biomedical processes. Fluorescence microscopy is an established tool and has contributed to many discoveries in the life sciences. This technique provides molecu ...

EPFL2017

We propose and experimentally demonstrate a system in which off-axis digital holographic microscopy is realized using a broadband illumination source. Single-shot holographic measurements are enabled, while the coherence noise is removed thanks to the broa ...

Spie-Int Soc Optical Engineering2015

We propose and experimentally demonstrate a device in which common-path interferometry combined with off-axis holographic geometry is used to realize a digital holographic camera which can be attached to the camera port of a conventional transmission micro ...

Spie-Int Soc Optical Engineering2014

Optical Coherence Correlation Spectroscopy

Stéphane Broillet

Questions such as biomolecular interactions, kinetics of enzymes, DNA conformational changes, cellular structures properties (among others) are addressed by characterizing the biological function of molecules. This function depends on their structure and t ...

EPFL2014

Fluorescence microscopy techniques are well established research tools and have proven their use in a large variety of biomedical applications. Microscopic molecular contrast is achieved by imaging fluorescent dyes that bind specifically to a molecule of i ...

EPFL2013

Optical Coherence Correlation Spectroscopy (OCCS)

Theo Lasser, Christophe Pache, Marcel Leutenegger, Arno Pino Bouwens, Stefan Geissbühler, Daniel Pawel Szlag, Akihiro Sato, Stéphane Broillet

We present optical coherence correlation spectroscopy (OCCS), a novel method to study the motion dynamics of nanoparticles within many observation volumes simultaneously. For this purpose, OCCS combines the key features of dark-field optical coherence micr ...

2013

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In digital holographic microscopy (DHM), the long coherence length of laser light causes parasitic interferences due to multiple reflections in and by optical components in the optical path of the microscope and thus degrades the image quality. The parasit ...

Spie-Int Soc Optical Engineering2013