Human Tumor Suppressor Genes

This lecture discusses human tumor suppressor genes, focusing on examples such as APC, BRCA1, BRCA2, SMAD4, NF-1, NF-2, and their associated cancer types. It explains the genetic predisposition to cancer, using retinoblastoma as an example to illustrate the role of the RB gene in tumor formation. The lecture also covers the Rb gene's location, function as a tumor suppressor, and the mechanisms of retinoblastoma development through mutations. Additionally, it explores the concepts of sporadic and hereditary retinoblastoma, mitotic recombination, and the inactivation of the Rb gene. The discussion extends to the molecular mechanisms behind retinoblastoma tumor formation, including deletions, mutations, and chromosomal abnormalities.