Ion Channels: Structure and Function

This lecture explores the significance of ion channels in various biological processes, from bacterial resistance to osmotic shock to neuronal signal transmission and pain modulation. The presentation delves into the mechanisms of ion channel activation, including ligand-gated and voltage-gated channels, and their role in active and passive ion transport through membranes. The instructor discusses the MWC model for ligand binding and channel opening, as well as the time evolution of channel states. Additionally, the lecture covers patch clamp measurements for studying ion transport, the two-state model for mechanosensitive channels, and the dynamics of sodium channels.