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Lecture
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
This lecture covers the chemical biology toolsets related to enzyme inhibition, including reversible (competitive, non-competitive, TS analog) and irreversible mechanisms. It also discusses small-molecule-based target modulation techniques like the Bump-Hole method and ABPP indirect profiling. Additionally, it explores transcriptome/genome-probing tools such as mRNA display and RNA aptamers. The lecture delves into proteome-level probing tools like the Amber suppressor technique and SILAC-BONCAT method, highlighting their applications in chemical biology.
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