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Lecture
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
This lecture covers the mechanisms of DNA repair, focusing on base excision repair (BER), nucleotide excision repair (NER), non-homologous end joining (NHEJ), and homologous recombination (HR). BER and NER require an intact second strand as a template for repair, while NHEJ is used when there is no sister chromatid available. HR is a high-fidelity process that uses a sister chromatid as a repair template. The lecture also discusses the consequences of mutations in DNA repair enzymes and inherited syndromes related to DNA repair defects, such as xeroderma pigmentosum and ataxia telangiectasia.