Organophosphate Insecticides: Toxicity and Treatment

This lecture discusses the toxicity and treatment of organophosphate insecticides, such as malathion and parathion. It covers their mechanism of action, including the formation of stable complexes with acetylcholinesterase, leading to symptoms like miosis, vision disorders, and respiratory issues. The presentation also explores the reactivation of aged enzyme-inhibitor complexes using cholinesterase reactivators like pralidoxime. Additionally, it delves into the potential late syndrome sequelae of poisoning, which can manifest as cognitive deficits. The lecture emphasizes the delicate use of treatments like atropine and respiratory assistance in cases of severe poisoning, highlighting the importance of understanding the risks associated with exposure to these toxic compounds.