Design of Immunogenic Vaccines

This lecture provides an overview of the design of immunogenic vaccines, focusing on the challenges faced in vaccine development, the history of immunotherapy, and the importance of antigens in T-cell responses. It discusses the two classes of successful vaccines, the issues with live-attenuated and inactivated vaccines, and the triumphs and challenges in cancer vaccine development. The lecture also covers the concept of neoantigens as ideal cancer vaccine targets, the use of adjuvants in modern vaccines, and the strategies for delivering vaccines effectively. It explores the role of microbes in delivering antigens to dendritic cells and the rudimentary components of vaccines.