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This lecture covers the fundamentals of epigenetics, focusing on histone modifications such as acetylation, methylation, and phosphorylation. It explains the structure of chromatin, the role of histones, and their impact on transcription. The instructor discusses the enzymes involved in histone modifications and the interplay between different types of modifications. Additionally, the lecture explores DNA methylation, its function in gene expression regulation, and the mechanisms of DNA de-methylation. The session concludes with a discussion on the heritability of epigenetic changes through mitosis and meiosis.