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This lecture covers the Second International Conference on Nutrition held in Rome in November 2014, focusing on global nutrition challenges and policies. It discusses macro- and micro-nutrients, dietary habits, nutritional reference values, and the importance of a balanced diet. The lecture also delves into food supplements, their consumption trends, and their role in preventing deficiencies. Furthermore, it explores the impact of vitamin supplementation on health outcomes, particularly in randomized clinical trials. The presentation concludes with insights on obesity, its causes, consequences, and management strategies, emphasizing the importance of a healthy lifestyle and balanced nutrition.