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This lecture discusses the global challenges related to food sustainability, nutrition, and health, exploring topics such as food expenditure in different countries, obesity prevalence, undernourishment, and the impact of climate change on agriculture. It delves into the need for increased agricultural production to feed the growing population, changes in diets, and the importance of food sustainability. The lecture also covers the complex interactions between nutrition and major diseases, as well as the ethical and interdisciplinary aspects of food production and consumption.