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1H MRS in the cerebellum was used to study the effect of 2-octynohydroxamic acid (2-octynoHA) treatment on the brain of bile duct ligated (BDL) rats (type C hepatic encephalopathy). The study included four groups of rats: negative control group (rats received a drug-free solution), suspension group (rats received a suspension of 2-octynoHA; 30 mg/kg, twice daily), solution group (rats received a solution of 2-octynoHA, 30 mg/kg, twice daily) and capsule group (rats received 2-octynoHA in enteric capsules; 10 mg once daily). 1H MRS measurements were performed on day 39 post-BDL surgery corresponding to the last day of treatment. The dataset contains RAW spectra (metabolites and water) prepared for LCModel quantification. Funded by Carigest
Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso