Occupational safety and health

Occupational safety and health (OSH) or occupational health and safety (OHS), also known simply as occupational health or occupational safety, is a multidisciplinary field concerned with the safety, health, and welfare of people at work (i.e. in an occupation). These terms also refer to the goals of this field, so their use in the sense of this article was originally an abbreviation of occupational safety and health program/department etc. OSH is related to the fields of occupational medicine and occupational hygiene. The goal of an occupational safety and health program is to foster a safe and healthy occupational environment. OSH also protects all the general public who may be affected by the occupational environment. According to the official estimates of the United Nations, the WHO/ILO Joint Estimate of the Work-related Burden of Disease and Injury, almost 2 million people die each year attributable to exposure to occupational risk factors. Globally, more than 2.78 million people die annually as a result of workplace-related accidents or diseases, corresponding to one death every fifteen seconds. There are an additional 374 million non-fatal work-related injuries annually. It is estimated that the economic burden of occupational-related injury and death is nearly four per cent of the global gross domestic product each year. The human cost of this adversity is enormous. In common-law jurisdictions, employers have the common law duty (also called duty of care) to take reasonable care of the safety of their employees. Statute law may, in addition, impose other general duties, introduce specific duties, and create government bodies with powers to regulate occupational safety issues: details of this vary from jurisdiction to jurisdiction. As defined by the World Health Organization (WHO) "occupational health deals with all aspects of health and safety in the workplace and has a strong focus on primary prevention of hazards." Health has been defined as "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.

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Summary

Model-based scale-up of a continuously operated consolidated bioprocess based on a microbial consortium for the production of ethanol

David Beat Dempfle

This work demonstrated that consolidated bioprocessing is a promising concept for conversion of lignocellulose to ethanol at industrial scale. CBP offers great cost saving potential, is feasible to be operated continuously and may be scaled up due to extensive knowledge of the process from a chemical engineering point of view.Cost savings of up to 27.5% of the total costs compared to conventional bioethanol production from lignocellulose, as stated by a techno-economic assessment, make continuous CBP the strongest lever to reduce processing costs of lignocellulosic ethanol. A cost sensitivity analysis identified scale and yield as the main cost-pushers from a process point of view, whereas the price level of the plant location has the highest impact on the investment conditions.To prove the feasibility of continuous CBP, and therefore the mentioned cost savings, experiments with a maximum titer of 3.258±0.007 g/L, a productivity of 0.025 g/(Lh) and constant enzyme production over 750h were conducted. Furthermore, the continuous experiments showed that experiments with identical volumetric oxygen transfer rate k_L a, but different oxygen fluxes per membrane area, showed titer differences of ca. 80% (1.83 g/L vs 3.26 g/L) in favor of setups with the large membrane surface. A rigorous process model was developed for continuously operated CBP. 9 species were considered (oxygen, glucose, total concentration Trichoderma reesei, secondary mycelia concentration of T. reesei, enzymes, cellulose, cellobiose, yeast density and ethanol). 8 of these 9 species needed to be modelled spatially resolved to account properly for mass transfer limitations. The fungal biofilm thickness d_f was found to be a critical parameter with an optimum for every membrane configuration. Smaller d_f reduced the fungal biofilm volume and thus, the enzyme production and larger d_f increased the diffusion path length causing shortage in nutrient supply as well as lower enzyme concentrations in the bulk. The enzyme synthesis rate of the secondary mycelia was fitted by reducing it by ca. 40% (0.67 FPU/(mLd) vs 1.152 (FPU/(mL*d) compared to batch models.With the process model as centerpiece, a scale-up framework consisting of the model and a set of non-dimensional parameters was developed to scale CBP from 2.7L laboratory scale to 130L pilot scale. The majority of the non-dimensional parameters could be kept constant during scale-up as requested by the similarity paradigm. Necessary changes were simulated with the model. Again, the fungal biofilm thickness d_f proved to be a relevant parameter for scale-up considerations. In general, the relative loss of biofilm volume is compensated by longer residence times since the residence time has by far the least impact on the process economics.Finally, popular rate-controlled separation techniques were investigated regarding their potential with CBP, since they offer the potential to reduce yeast inhibition, to avoid separation limitations by the azeotrope and they are not bound to the vapor-liquid-equilibrium of highly diluted ethanol-water mixtures. However, most of the mechanisms fail to handle the solids of the fermentation broth. Pervaporation, being the most promising concept for in-situ product removal, would be a cost-saving alternative to distillation for batch operation, but is limited by an unfavorable vapor-liquid equilibrium due to low bulk concentrations during continuous operation.

EPFL2022

Identification of parameters affecting the outcome of biochemical methane potential (BMP) tests

Jonas Stöckli

Anaerobic digestion of organic waste to methane gas (CH4) is an attractive method to produce renewable energy. Due to the trend towards the reuse of waste and away from fossil energy sources, this technology saw a worldwide development in the recent years. A fundamental parameter in this domain is the Biochemical Methane Potential (BMP), which defines the amount of CH4 which can be produced out of a certain organic substrate. Such information is essential in order to plan and optimise anaerobic digestion plants, and to evaluate the reactor feed with a new substrate or a new substrate combination (co-digestion). BMPs are assessed in batch test, which can be regarded as the simulation of a full-scale biogas plant. Two experiments are required, the test in which the test substrate is digested on the inoculum, and the blank, in which the inoculum is digested alone. The part of the inoculum which can be digested is called endogenous substrate. Since the test experiment produced not only on the test substrate but only on the endogenous substrate, the CH4 production on the test substrate alone is obtained by the subtraction of the test production minus the blank production. The units of a BMP are generally indicated in litre of CH4 per gram of volatile solids (VS) test substrate [L/gVS]. Despite the importance and the wide application of this parameter, its exact determination remains a challenging issue and results are often not consistent in between (inter-) and within (intra-) laboratories. Experimental protocols exist but do not lead to a satisfactory BMP tests consistency neither. The aim of this study was to identify parameters affecting the outcome of BMP tests, based on the investigation of two different data sets. An inter-laboratory study of BMP tests providing the final BMP values of 327 experiments and information about 40 related experimental parameters, and a second data set containing the complete CH4 production curves of 136 BMP experiments provided by one single laboratory. The method consisted in graphical and statistical analysis (Mixed Effect Modelling), using [R] programming language and software environment. This study found out, that a significant part of the inter-laboratory BMP inconsistency can be explained by an imprecise assessment of the VS, which was not expected. As the VS of the substrate are directly implied in the computation of the BMP, the impact was significant and therefore the BMP were corrected regarding the VS imprecision. With these data, up to 70% of the inconsistency of BMPs could be explained by inter-laboratory effects. The statistical analysis led to the conclusion that the concentration of the endogenous substrate and the moisture content in the digestate would be the principal factors affecting the outcome of BMP tests. An effort was made to identify and correct errors contained in CH4 production curves, which turned out to be delicate for certain cases. Also indications regarding the precision and the reliability of BMPs were formulated. Further, the investigation of the CH4 production curves led to the development of a new method in order to compute the BMP result. This method was based on the fact, that a certain inoculum reaches always the same slope toward the end of the experiment, no matter what was digested before. The advantage of this method would be that the experiment end-point could be set clearly and that the concentration of the endogenous substrate would not have an impact on the outcome of a BMP test. According to the findings of this report, it was proposed to add the following requirements into experimental protocols for BMP tests: Tests, blanks and the analysis of VS should be carried out in triplicates and their standard deviation should be indicated for each of them, together with the BMP result If triplicates contain set-up errors, these experiments must be repeated, including the corresponding blank/test In the annex: An experimental protocol for the TS and VS analyses An indication of a required moisture content of the digestate (mechanism to investigate in detail first) An indication of the range of required VS concentrations or a maximal production rate for blank tests according to certain experimental conditions (mechanism to investigate in detail first). This report identified several parameters, which contribute to the inter-laboratory inconsistency of BMPs. These findings should be investigated further in order to prove and quantify their impact. An effort should be made to demonstrate the newly developed BMP-computation-method, which could eventually lead to more consistent results. The limitation of this study was, that a relatively low amount of data was available compared to their characteristics. Consequently, the findings could only be proven on a few examples and should therefore only be seen as evidences. Further, this led also to the risk of overfitting, since a relative high amount of parameters needed to be included into the statistical model.

2012

Elimination of micropollutants using Engineered Constructed Wetlands - A laboratory scale study

Tran Long Dien Ho

2010

Topics in infectious diseases

An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response.

Chemical kinetics

Chemical kinetics, also known as reaction kinetics, is the branch of physical chemistry that is concerned with understanding the rates of chemical reactions. It is different from chemical thermodynamics, which deals with the direction in which a reaction occurs but in itself tells nothing about its rate. Chemical kinetics includes investigations of how experimental conditions influence the speed of a chemical reaction and yield information about the reaction's mechanism and transition states, as well as the construction of mathematical models that also can describe the characteristics of a chemical reaction.

Fire safety

Fire safety is the set of practices intended to reduce destruction caused by fire. Fire safety measures include those that are intended to prevent the ignition of an uncontrolled fire and those that are used to limit the spread and impact of a fire. Fire safety measures include those that are planned during the construction of a building or implemented in structures that are already standing and those that are taught or provided to occupants of the building. Threats to fire safety are commonly referred to as fire hazards.