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Concept
Lipid profile
Summary
A lipid profile or lipid panel is a panel of blood tests used to find abnormalities in lipids, such as cholesterol and triglycerides. The results of this test can identify certain genetic diseases and can determine approximate risks for cardiovascular disease, certain forms of pancreatitis, and other diseases.
Lipid panels are usually ordered as part of a physical exam, along with other panels such as the complete blood count (CBC) and basic metabolic panel (BMP).
The lipid profile typically includes:
Low-density lipoprotein (LDL)
High-density lipoprotein (HDL)
Triglycerides
Total cholesterol
Using these values, a laboratory may also calculate:
Very low-density lipoprotein (VLDL)
Cholesterol:HDL ratio
The lipid profile tests are of 7 types:
Total lipids
Serum total cholesterol
serum HDL cholesterol
Total cholesterol/HDL cholesterol ratio
Serum triglycerides
Serum Phospholipids
Electrophoretic fractionation to determination percentage of
(a) Chylomicrons
(b) LDL
(c) VLDL
(d) HDL
Recommendations for cholesterol testing come from the Adult Treatment Panel (ATP) III guidelines, and are based on many large clinical studies, such as the Framingham Heart Study.
For healthy adults with no cardiovascular risk factors, the ATP III guidelines recommend screening once every five years. A lipid profile may also be ordered at regular intervals to evaluate the success of lipid-lowering drugs such as statins.
In the pediatric and adolescent population, lipid testing is not routinely performed. However, the American Academy of Pediatrics and the National Heart, Lung, and Blood Institute (NHLBI) recommend that children aged 9–11 be screened once for severe cholesterol abnormalities. This screening can be valuable to detect genetic diseases such as familial hypercholesterolemia that can be lethal if not treated early.
Traditionally, most laboratories have required patients to fast for 9–12 hours before screening. However, studies have questioned the utility of fasting before lipid panels, and some diagnostic labs routinely accept non-fasting samples.
Official source
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