The emergence of new high-performance materials and equipment, as well as advancements in numerical calculation techniques, have allowed base isolation to take its place among the strategies used by engineers in earthquake resistant design. Despite the enormous advantages of implementing seismic isolation, its applications have so far been limited to critical infrastructures (hospitals, re stations, etc.) located in earthquake-prone areas. The relatively high costs associated with the installation of an isolation system constitute a major constraint when choosing the structural system of a building. In this Master's project, a 4 storey composite-steel administrative building located in Sion (Switzerland) is designed, according to several importance classes, in order to study the relevance of the installation of a base isolation system. Two dierent design methodologies are adopted to determine the dimensions of the foundations and the main load-bearing elements of two buildings, one with a xed-base and the second with a seismic isolation system. The results of the various design procedures clearly indicate that the choice of installing isolating supports is not obvious. Indeed, when the building under study is considered as a critical infrastructure, signicant savings, up to more than 20% in terms of building materials, can be achieved for an isolated structure. On the other hand, for an ordinary structure, the additional costs associated with the installation of isolated supports cannot be oset by savings in construction materials. These results reinforce the perspective that, in the presence of an ordinary building, the traditional xed-base solution remains the most ecient. However, despite its relatively high cost, a base isolated building performs better during a seismic event, with structural demands and damages signicantly mitigated compared to a xed-base building. To compare the responses of the two structural systems, two non-linear models are created on OpenSEES. Two dynamic analyses are then conducted for two groups of 40 seismic records, calibrated according to two characteristic intensities. Based on the results obtained, it is clear that the xed building undergoes higher demands (in deformations and accelerations in particular) than its isolated counterpart. These demands are then used and transformed into a decision variable (in this case, repair costs) through loss analyses conducted on the EarL software. These analyses show that after the occurrence of an earthquake, the repair costs of a conventional building can reach 25 % of the initial construction costs, almost 10 times the value obtained in the case of a base isolated building. This Master's project demonstrates that despite the high initial cost of base isolation technologies, their implementation can not only be amortized through possible material savings, but also, through the reduction of repair costs due to a better performance of the building over its lifecycle.