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We present a finite element based simulation and analysis method to describe the spatial extent of stimulation and the effects of electrode–tissue interactions in subretinal prostheses. In particular, we estimate the threshold stimulation current needed to ...
Purpose: The timing of bipolar intracardiac electrograms (EGMs) during atrial fibrillation (AF) reflects the dynamics of AF wavelets. The extent of synchronization between EGMs is an indirect measure of AF spatial organization. Our study intends to determi ...
Robberechts Q, Wijnants M, Giugliano M, De Schutter E. Longterm depression at parallel fiber to Golgi cell synapses. J Neurophysiol 104: 3413-3423, 2010. First published September 22, 2010; doi:10.1152/jn.00030.2010. Golgi cells (GoCs) are the primary inhi ...
Interactions among neurons can take place in a wide variety of forms. It is the goal of this thesis to investigate the properties and implications of a number of these interactions that we believe are relevant for information processing in the brain. Neuro ...
We present an electrical impedance based biosensor on a microfluidic cell culture platform that enables label-free and re- al-time investigation of drug toxicity-induced effects on hepatocytes. The temporal evolution of the impedance at different frequenci ...
We applied microelectrode array (MEA) recordings to study the generation and propagation of epileptform activity in various connected regions of cortico-hippocampal slices obtained from SynapsinI/II/III knockout (TKO) mice and the effects of the synaptic v ...
Recently, CMOS-based microelectrode arrays containing a high-density of electrodes have emerged as a tool enabling recording the extracellular neural electrical activity of cell cultures at subcellular resolution. However, several improvements in areas suc ...
An innovative readout channel, based on analog amplitude modulation of the signals recorded by each sensing site, is developed for high-density CMOS-based microelectrode arrays. A single amplification stage simultaneously records the neural activity acquir ...
An analytical calculation of the acoustic transmission loss of sound propagating through a thin cylindrically curved piezoelectric membrane, which is rigidly clamped at its straight ends, is presented. The membrane is placed inside an acoustic tube and con ...
Neurons cultured in vitro on MicroElectrode Array (MEA) devices connect to each other, forming a network. To study electrophysiological activity and long term plasticity effects, long period recording and spike sorter methods are needed. Therefore, on-line ...