Publications related to Macrophage

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Bernard Schneider, Nicholas David James

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG digesti ...

Society for Neuroscience2014

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Nikolaos Stergiopoulos, Katia Galan, Rafaela Fernandes Da Silva

Pharmacological treatments targeting CXC chemokines and the associated neutrophil activation and recruitment into atherosclerotic plaques hold promise for treating cardiovascular disorders. Therefore, we investigated whether FK866, a nicotinamide phosphori ...

Schattauer2014

Cell-wall deficient L. monocytogenes L-forms feature abrogated pathogenicity

Nicola Harris

Stable L-forms are cell wall-deficient bacteria which are able to multiply and propagate indefinitely, despite the absence of a rigid peptidoglycan cell wall. We investigated whether L-forms of the intracellular pathogen L. monocytogenes possibly retain pa ...

Frontiers Research Foundation2014

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Kristina Schoonjans, Alessia Perino, Matthias Alexander Sokrates Stein, Mitsunori Nomura, Thijs Pols

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression

Michele De Palma, Mario Leonardo Squadrito

The immunosuppressive tumor microenvironment represents a major hurdle to cancer therapy. We developed a gene transfer strategy into hematopoietic stem cells (HSCs) to target transgene expression to tumor-infiltrating monocytes/macrophages. Using a combina ...

2014

Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes

Harm-Anton Klok, Solenne Desseaux

Thin, thermoresponsive polymer coatings that allow to reversibly modulate cell adhesion and detachment are attractive substrates for cell sheet engineering. Usually, this is accomplished by applying thin poly(N-isopropylacrylamide) (PNIPAM) coatings, which ...

American Chemical Society2014

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Stewart Cole, Claudia Sala, Ruben Hartkoorn, Andrej Benjak, Anthony Vocat, Ming Zhang, Jan Lars Rybniker, Jeffrey Chen, Edina Rita Székely

Mycobacterium tuberculosis (Mtb) requires protein secretion systems like ESX-1 for intracellular survival and virulence. The major virulence determinant and ESX-1 substrate, EsxA, arrests phagosome maturation and lyses cell membranes, resulting in tissue d ...

Cell Press2014

Survival of Free and Encapsulated Human and Rat Islet Xenografts Transplanted into the Mouse Bone Marrow

Jutta Christine Wandrey, Redouan Mahou, Yannick Müller

Bone marrow was recently proposed as an alternative and potentially immune-privileged site for pancreatic islet transplantation. The aim of the present study was to assess the survival and rejection mechanisms of free and encapsulated xenogeneic islets tra ...

Public Library of Science2014

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Eva Sabrina Gollwitzer, Nicola Harris, Benjamin John Marsland

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the ...

Nature Publishing Group2014

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Macrophage

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Cell-wall deficient L. monocytogenes L-forms feature abrogated pathogenicity

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression

HTT-lowering reverses Huntington's disease immune dysfunction caused by NF kappa B pathway dysregulation

Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Survival of Free and Encapsulated Human and Rat Islet Xenografts Transplanted into the Mouse Bone Marrow

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

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Chat with Graph Search

Cell-wall deficient L. monocytogenes L-forms feature abrogated pathogenicity

HTT-lowering reverses Huntington's disease immune dysfunction caused by NF kappa B pathway dysregulation

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Survival of Free and Encapsulated Human and Rat Islet Xenografts Transplanted into the Mouse Bone Marrow

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis