Concept
Channel blocker
Related publications (32)
Structural heterogeneity of the ion and lipid channel TMEM16F
Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...
Berlin2024From Surfactants to 3D Printing: How Ion-Chelator Pair Interactions Affect the Mechanical Properties of Bioinspired Materials
The remarkable adaptability observed in marine ecosystems has often inspired researchers when developing new soft materials. The research undertaken in this thesis explores how ion chelator pair interactions influence the mechanical properties of bioinspir ...
EPFL2024Article Structure and functionality of a multimeric human COQ7:COQ9 complex
Matteo Dal Peraro, Luciano Andres Abriata
Coenzyme Q (CoQ) is a redox-active lipid essential for core metabolic pathways and antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined "complex Q" metabolon. Here, we present structure-function analyses of a lipi ...
CELL PRESS2022A perspective on multi-channel technology for the next-generation of GaN power devices
Elison de Nazareth Matioli, Luca Nela
The outstanding properties of Gallium Nitride (GaN) have enabled considerable improvements in the performance of power devices compared to traditional silicon technology, resulting in more efficient and highly compact power converters. GaN power technology ...
AIP Publishing2022Modeling of Short-Channel Effects in GaN HEMTs
In this article, we propose an explicit and analytic charge-based model for estimating short-channel effects (SCEs) in GaN high-electron-mobility transistor (HEMT) devices. The proposed model is derived from the physical charge-based core of the ecole Poly ...
2020Spatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial Ions
Sylvie Roke, Aleksandra Radenovic, Orly Bagunu Tarun, Maksim Eremchev
Ion channels are responsible for numerous physiological functions ranging from transport to chemical and electrical signaling. Although static ion channel structure has been studied following a structural biology approach, spatiotemporal investigation of t ...
2019Subaquatic slope instabilities: The aftermath of river correction and artificial dumps in Lake Biel (Switzerland)
Alfred Johny Wüest, Laëtitia Meuriot, Nathalie Dubois
River engineering projects are developing rapidly across the globe, drastically modifying water courses and sediment transfer. Investigation of the impact of engineering works focuses usually on short-term impacts, thus a longer-term perspective is still m ...
2019Human Cortical Pyramidal Neurons: From Spines to Spikes via Models
Idan Segev, Ruth Benavides Piccione, Guy Eyal, Yair Deitcher
We present detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal Na(+) spikes that provided new insights into signal processing and computational capabil ...
2018